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Quiz Week 6-7 Block FMS I

Total questions: 40

Worksheet time: 20mins

Name
Class
Date
1.

Which of following statement is CORRECT about passive transport?

a)

Movement of substance against concentration gradient with energy cost

b)

Movement of water from hypertonic solution to hypotonic solution without energy cost

c)

Movement of substance down its electrochemical gradient with or without carrier protein

d)

Na+/K+ pump

e)

None of the above

2.

Which one of the following is the correct order of Metastasis?

a)

Invasion, Intravasation, Extravasation, Transport, Colonization

b)

Invasion, Intravasation, Transport, Extravasation, Colonization

c)

Intravasation, Extravasation, Transport, Colonization, Invasion

d)

Intravasation, Extravasation, Transport, Invasion, Colonization

e)

Intravasation, Extravasation, Invasion, Transport, Colonization

3.

Which of the following is CORRECT mechanisms of biochemical basis for signal transduction?

a)

protein conformational changes

b)

covalent protein modifications

c)

altered rates of gene expression

d)

None of above

e)

All of above

4.

The invasion of cancer cells through the basal membrane into a blood or lymphatic vessel, is also called:

a)

Extravasation

b)

Inflammation

c)

Intravasation

d)

Infiltration

e)

Colonization

5.

Which of the following best describes Oncogene?

a)

An oncogene codes for DNA Glycosylase

b)

An oncogene is a dominantly expressed mutated gene that gives a cell a growth advantage

c)

An oncogene codes for cell cycle control protein

d)

BRCA1 is an example of Oncogene

e)

An oncogene codes for a protein that prevents the cell from undergoing apoptosis

6.

Cancer therapeutic strategies in Epigenetics may include inhibition of following enzymes, except:

a)

Histone Demethylase

b)

Histone Deacetylase

c)

DNA Glycosylase

d)

Histone Methyltransferase

e)

DNA Methyltransferase

7.

Which one of the following statements best describe the role of BRCA1 in breast carcinogenesis?

a)

induces angiogenesis

b)

creates the Angelina effect

c)

excess of Estrogen Receptor

d)

loss of genomic stability if mutated

e)

single strand break repair

8.

Modes of cell to cell signaling which two adjacent cells must make physical contact in order to communicate is ...

a)

Endocrine

b)

Neuronal

c)

Paracrine

d)

Juxtacrine

e)

Autocrine

9.

A tumor is any abnormal proliferation of cells, which may be either benign or malignant. How do the cells of benign and malignant tumors differ?

a)

Benign cells grow fast and are small; malignant cells grow slow but large

b)

Benign cells growth into adjacent tissue; malignant cells displace adjacent tissue

c)

Benign cells have metastasis potential; malignant cells have apoptosis potential

d)

Malignant cells are not encapsulated; benign cells are encapsulated

e)

Malignant cells have well defined border; benign cells' border are less defined

10.

The INCORRECT characteristic of G-protein linked receptor is ...

a)

Example of G-protein linked receptor is epinephrine receptor

b)

The binding of ligand to G-protein linked receptor activates dimerization of receptor

c)

Receptor activation causes dissociation of α subunits from βγ subunits

d)

Each is made of a single polypeptide chain that threads back and forth across the lipid bilayer seven times

e)

Indirectly regulate activity of a separate plasma-membrane-bound target protein (could be enzyme or ion channel

11.

Which of the following is INCORRECT statement of action potential?

a)

The repolarization is maintained by active Na+/K+ pump

b)

Membrane resting potential is at -70 mV

c)

Stimulus will open Na+ channel that results in the reduced membrane negativity

d)

Initiated by opening of K+ channel

e)

Initiated by depolarization of membrane potential

12.

What DNA virus has been linked to a type of human cancer?

a)

Human T-cell lymphotropic virus type 1

b)

Human Immunodeficiency Virus

c)

Hepatitis C Virus

d)

Dengue Virus

e)

Hepatitis B Virus

13.

The second messenger that is resulted from the activation of receptor tyrosine kinase is ...

a)

G-protein

b)

Calmodulin

c)

Adenylyl cyclase

d)

Diacylglycerol

e)

CAM-kinase

14.

Cancer in situ means it _____________

a)

dies quickly

b)

spreads quickly

c)

invades normal tissue

d)

not infectious

e)

is found in one place

15.

The initiation of signal transduction is when the first signal binds to its receptor on target cell thus initiates the changes/activity in the cells. There are several types of signal molecules. Acetylcholine is a signal molecule that categorized as ...

a)

Contact-dependent signal molecules

b)

Local mediators

c)

Hormones

d)

Neurotransmitters

e)

Cytokines

16.

The killing/apoptosis of cell by lymphocytes through Fas binding to Fas ligand on viral infected cell, is an example of cell communication through ...

a)

Endocrine

b)

Autocrine

c)

Contact-dependent

d)

Paracrine

e)

Neuronal

17.

As tumors expand, diffusion distances from the existing vascular supply increase resulting in a condition called:

a)

Hypoxia

b)

Anoxia

c)

Dyslexia

d)

Normoxia

e)

Hypoxemia

18.

Which of the following is the CORRECT statement of inhibitory neurotransmitters?

a)

Open cation channels such as Na+

b)

Causes depolarization

c)

Example of inhibitory neurotransmitter is adrenaline

d)

Open Cl or K channels

e)

All above are correct

19.

Intracellular signaling protein that modifies the activity of signaling proteins, called as

a)

Modulator protein

b)

Latent gene regulatory protein

c)

Messenger protein

d)

Anchoring protein

e)

Relay protein

20.

Which error in DNA is most likely generated during DNA Replication?

a)

Deamination

b)

Alkylation

c)

Depurination

d)

Depyrimidination

e)

Mismatch

21.

Which one of the following statements is not characteristic of cancer cells?

a)

activate metastasis

b)

sustain proliferative signaling

c)

avoiding growth suppressors

d)

sensitive to cell death

e)

induce angiogenesis

22.

Which is the INCORRECT factor affecting diffusion rate?

a)

Molecular size

b)

Gravitational force

c)

Steepness of concentration gradient

d)

Transcription factors

e)

Temperature

23.

What is the correct order of steps in Carcinogenesis?

a)

Promotion, Initiation, Progression

b)

Promotion, Progression, Initiation

c)

Initiation, Promotion, Progression

d)

Initiation, Progression, Promotion

e)

Progression, Promotion, Initiation

24.

Following is the correct order or substances based by its permeability crossing the membrane from the highest to the lowest:

a)

Ion – small nonpolar molecule - small uncharged polar molecule – large uncharged polar molecule

b)

Small uncharged polar molecule – small nonpolar molecule – ion - large uncharged polar molecule

c)

Small nonpolar molecule - small uncharged polar molecule –– large uncharged polar molecule – ion

d)

Small uncharged polar molecule – small nonpolar molecule – large uncharged polar molecule – ion

e)

Ion - small uncharged polar molecule – small nonpolar molecule – large uncharged polar molecule

25.

Nucleotide Excision Repair is activated when the following condition occurs:

a)

Damage of single nucleotide

b)

Helix-distorting DNA lesions

c)

DNA insertion mutation

d)

Mismatch of nucleotide

e)

Double strand DNA damage

26.

Proto-oncogenes can be transformed to oncogenes by all of the following mechanisms, EXCEPT:

a)

Chromosomal rearrangements

b)

Insertions that lead to a hyperactive gene product

c)

Mutations in the promoter region that lead to increased transcription

d)

Gene amplification

e)

Elimination of their start signals for translation

27.

Controls that link the integrity of the genome with progression through the cell cycle are known as:

a)

receptors

b)

transcription factors

c)

deacetylators

d)

checkpoints

e)

growth factors

28.

Of the many hallmarks of cancer, which one is put to use when imaging cancer using PET:

a)

Limitless replicative potential

b)

Sustained angiogenesis

c)

Self-sufficiency in growth signal

d)

Evading apoptosis

e)

Reprogramming metabolism

29.

The followings best describe epigenetic related events that may contribute to the formation of cancer:

a)

Hypermethylation of BRCA1

b)

Overexpression of DNA methyl transferase

c)

Overexpression of Histone Deacetylase

d)

A and B

e)

A, B and C

30.

Cancer is often the result of activation of ____to____ and the inactivation of ____ genes.

a)

oncogenes, proto-suppressor genes, proto-genes

b)

oncogenes, tumor-suppressor genes, proto-oncogenes

c)

proto-oncogenes, oncogenes, tumor-suppressor genes

d)

oncogenes, proto-oncogenes, tumor-suppressor genes

e)

proto-suppressor genes, suppressors, oncogenes

31.

The correct order of glucose transport into the cells is:

a)

2 – 1 – 3 – 4 – 5

b)

5 – 2 – 3 – 1 – 4

c)

1 – 2 – 3 – 5 – 4

d)

2 – 3 – 1 – 4 – 5

e)

5 – 2 – 1 – 3 – 4

32.

The correct type of membrane protein that functions to help cells stick together to form tissue is ...

a)

GTP binding protein

b)

Adenylyl cyclase

c)

MHC

d)

Signal transduction protein

e)

Cadherin

33.

Intracellular signaling protein that increases the signal by producing large number of intracellular mediators or activating downstream intracellular proteins, called as

a)

Transducer protein

b)

Amplifier protein

c)

Scaffold protein

d)

Adaptor protein

e)

Relay protein

34.

Which is not common type of phospholipid membrane?

a)

Sterol

b)

Phosphatidylserine

c)

Phospholipase C

d)

Phosphatidylcholine

e)

Galactocerebroside

35.

Which of the following is INCORRECT in term of CFTR and its function?

a)

Reabsorb sodium chloride (NaCl) as the sweat passes along the tubule of sweat gland ducts and producing a hypertonic sweat

b)

Coordinates the regulation of Na absorption by ENaC and Cl secretion by CFTR maintains the correct depth and composition of the ASL in trachea

c)

CFTR is located in apical membrane of pancreatic duct cells and plays a key role in ductal bicarbonate (HCO3-) secretion

d)

CFTR is located in apical membrane of pancreatic duct cells and plays a key in maintaining the appropriate volume and pH of pancreatic secretions

e)

CFTR protein is a channel protein that controls the flow of H2O and Cl- ions in and out of cells inside the lungs

36.

Glucagon acts as signal for liver to breakdown glycogen, through ...

a)

Inactivation of glycogen phosphorylase

b)

Stimulate the movement of GLUT to the membrane

c)

Inactivation of glycogen synthase

d)

Activation of insulin signaling

e)

Activation of IRS-1 protein

37.

Type of membrane transport protein that can transport two different substances simultaneously into the cell, but acts as passive transport for a substance and active transport for the other substance, known as ...

a)

Antiporter

b)

ATP-binding cassette transporter

c)

ATP-powered pump

d)

Uniporter

e)

Symporter

38.

Which of the following is true of methyl groups’ effect in the epigenetic mechanism? They directly inhibit __________________

a)

Transcription

b)

Protein translation

c)

Ribosome assembly

d)

Protein stability

e)

Nuclear pore transport

39.

Which one of the following sequences best describe the steps leading to tumor angiogenesis?

a)

3, 1, 2, 5, 4, 6

b)

5, 3, 1, 2, 6, 4

c)

3, 5, 1, 6, 2, 4

d)

5, 1, 3, 2, 4, 6

e)

5, 1, 6, 3, 4, 2

40.

Membrane protein that functions by binding the signal or ligand that leads to the production of second signal that causes a cellular response is...

a)

Extracellular matrix

b)

Membrane receptor

c)

Insulin

d)

First messenger

e)

Chaderin

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