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WorksheetsUntitled Quiz
Total questions: 40
Worksheet time: 14mins
Describe the difference between the laminar flow cabinet used in TPN/IV Admixture and Cytotoxic Reconstitution in your Hospital.
TPN/IV Admixture: Typically uses horizontal laminar airflow to protect the product from contamination. Cytotoxic: Uses vertical laminar airflow to protect both the product and the operator from exposure to hazardous drugs.
TPN/IV Admixture: Uses vertical laminar airflow to protect the operator only. Cytotoxic: Uses horizontal laminar airflow to protect the product only.
TPN/IV Admixture: Uses no airflow protection. Cytotoxic: Uses horizontal laminar airflow to protect the product from contamination.
TPN/IV Admixture: Uses vertical laminar airflow to protect the product from contamination. Cytotoxic: Uses horizontal laminar airflow to protect both the product and the operator from exposure to hazardous drugs.
What is the direction of airflow inside the laminar flow cabinet used in cytotoxic drug reconstitution?
Vertical airflow (from top to bottom)
Horizontal airflow (from back to front)
Diagonal airflow (from left to right)
Circular airflow
What is the pressure inside the cytotoxic drug cabinet?
Negative pressure
Positive pressure
Atmospheric pressure
High pressure
What is a Clean Room?
A clean room is a controlled environment with a low level of pollutants such as dust, airborne microbes, aerosol particles, and chemical vapors, used in pharmaceutical and scientific research to maintain product and process integrity.
A clean room is a type of laundry facility used for washing industrial uniforms.
A clean room is a recreational area designed for relaxation and entertainment in offices.
A clean room is a kitchen space in restaurants dedicated to preparing only vegetarian food.
What are the purpose of having HEPA filter in a clean room?
HEPA filters are used in clean rooms to remove airborne particles and contaminants, ensuring a sterile environment for sensitive processes.
HEPA filters are used in clean rooms to increase humidity levels for plant growth.
HEPA filters are used in clean rooms to add fragrance to the air.
HEPA filters are used in clean rooms to regulate temperature for comfort.
The purpose of using Decon 90 in managing cytotoxic spill is:
to neutralize and clean hazardous cytotoxic substances
to provide personal protective equipment
to dispose of cytotoxic waste
to prevent spills from occurring
Decon 90 is used during which stage of cytotoxic agent preparation?
Before preparation to clean surfaces
After preparation to disinfect equipment
During cleaning of biosafety cabinet after complete preparation and spillage incidence
After administration to clean patient area
How often do you need to clean the cytotoxic cabinet?
Before and after preparation
Spill incidence
Daily
Never
When do you need to disinfect the passbox?
Before and after each use
Only at the end of the day
Once a week
Only when visibly dirty
The physical parameters that need to be monitored daily in a clean room include:
Temperature, humidity, differential pressure,
Noise level, light intensity, and vibration
Water quality, chemical concentration, and waste output
Staff attendance, equipment age, and cleaning schedule
The Grade of a Clean Room that houses the Laminar Flow Cabinet is:
Grade A
Grade B
Grade C
Grade D
The rubber stopper on a vial should be cleaned with an alcohol swab
before placing the vial into the laminar flow work bench.
immediately upon placing the vial into the laminar flow work bench.
immediately prior to entering the port with a sterile needle.
before any of the sterile compounding process
To prevent coring of a rubber stopper in vials, the compounder should insert the needle
with the bevel tip and then applying lateral and downward pressure
with the bevel tip and then applying vertical and downward pressure
with the bevel tip and then applying downward pressure with the bevel side facing the stopper
with the bevel tip and then applying downward pressure while twisting the needle
When reconstituting a drug, inject the diluent
rapidly into the vial and vigorously shake to dissolve the powder.
rapidly into the vial and allow it to set in the hood until the powder is dissolved
slowly into the vial and rotate or rock the vial to dissolve the powder.
slowly into the vial and allow it to set in the hood until the powder is dissolved.
Prepare the following injections in appropriate syringes size: Drug: A, Conc: 100mg/10mL, Dose: 8mg, What is the syringe size that we can use?
3 mL
5 mL
10 mL
1 mL
Prepare the following injections in appropriate syringes: Drug: C, Conc: 25mg/mL, Dose: 65mg, What is the volume of the drug?
2.6 mL
1.5 mL
3.0 mL
5.0 mL
Prepare the following injections in appropriate syringes: Drug: I, Conc: 10,000u/2mL, Dose: 6000u, What is the size of syringe that we can use?
3 mL
1 mL
5mL
10mL
List out 3 items of PPE (personal protective equipment) used in cytotoxic drug reconstitution.
a. Gloves b. Gown c. Respirator
a. Apron b. Slippers c. Hair gel
a. Shorts b. Sunglasses c. Scarf
a. T-shirt b. Cap c. Watch
A bottle of unreconstituted gemcitabine falls to the floor and breaks. How do you contain the drug from spreading?
Wet gauze with Decon 90/water and lay over the spill
Sweep up the broken glass and dispose of it in regular trash.
Wipe the spill with Decon 90
Leave the spill and wait for it to evaporate.
A respirator provides better protection than a surgical mask during cytotoxic drug reconstitution because:
it protects user from aerosol
it is more comfortable to wear for long periods
it is less expensive than a surgical mask
it is easier to dispose of after use
Patient excreta should be treated like cytotoxic waste up to __________ after chemotherapy.
7 days
12 hours
24 hours
72 hours
Extravasation of cytotoxic drug refers to:
The accidental leakage of a cytotoxic drug into surrounding tissues during intravenous administration
The intentional injection of a cytotoxic drug into muscle tissue
The absorption of a cytotoxic drug through the skin
The oral ingestion of a cytotoxic drug
List out the symptoms for both types of extravasants:
a. Vesicant: Tissue necrosis b. Irritant: Itchiness
a. Vesicant: Itching, numbness, bruising b. Irritant: Dryness, peeling, rash
a. Vesicant: Swelling, fever, chills b. Irritant: Ulceration, bleeding, scarring
a. Vesicant: Headache, dizziness, nausea b. Irritant: Cough, sneezing, congestion
Name 2 drugs from each group: a. Vesicant: i. __________ ii. __________ b. Irritant: i. __________ ii. __________
a. Vesicant: Doxorubicin, Vincristine b. Irritant: Etoposide, Paclitaxel
a. Vesicant: Cyclophosphamide, Etoposide b. Irritant: Vincristine, Doxorubicin
a. Vesicant: Carboplatin, Etoposide b. Irritant: Doxorubicin, Vincristine
a. Vesicant: Etoposide, Carboplatin b. Irritant: Vincristine, Doxorubicin
Name the type of compress for extravasation of these drugs:
a. Doxorubicin: Cold compress, b. Etoposide: Warm compress, c. Vinorelbine: Warm compress
a. Doxorubicin: Warm compress, b. Etoposide: Cold compress, c. Vinorelbine: Cold compress
a. Doxorubicin: Warm compress, b. Etoposide: Warm compress, c. Vinorelbine: Cold compress
a. Doxorubicin: Cold compress, b. Etoposide: Cold compress, c. Vinorelbine: Warm compress
What is the minimum value for these haematological results required for patient to undergo chemotherapy?
a. Haemoglobin: 10 g/dL
b. Neutrophil: 1.5 x 103 /UL
c. Platelet: 100 x 103 /UL
a. Haemoglobin: 8 g/dL
b. Neutrophil: 1.0 x 103 /UL
c. Platelet: 80 x 103 /UL
a. Haemoglobin: 12 g/dL
b. Neutrophil: 2.0 2.0x103 /UL
c. Platelet: 150 150x103 /UL
a. Haemoglobin: 9 g/dL
b. Neutrophil: 1.2 x 10^3/UL
c. Platelet: 90 x 10^3/UL
Patient Suitability for Chemotherapy Assessment K.P. is an 18-year-old about to begin chemotherapy for acute lymphoblastic leukemia. On today’s complete blood count (CBC), his hemoglobin (Hgb) is 7 g/dL. Which one of the following is the correct treatment?
Start K.P. on epoetin alfa 150 units/kg.
Transfuse K.P. with packed red blood cells (RBCs).
Delay chemotherapy treatment until Hgb recovers.
Reduce chemotherapy doses to prevent further decreases in Hgb
Patient Suitability for Chemotherapy Assessment 3. B.B. is a 38-year-old woman who completed six cycles of FAC chemotherapy (i.e., cyclophosphamide 500mg/m2, doxorubicin 50 mg/m2, and 5-fluorouracil 500 mg/m2) 6 months ago for metastatic breast cancer. Her latest computed tomographic scan shows increasing sites of metastatic disease. Because she responded so well to FAC in the past, her oncologist wishes to use it again. Which one of the following statements is the most correct?
B.B. has not reached the appropriate cumulative dose of doxorubicin
B.B. has reached the appropriate cumulative dose of doxorubicin
B.B. should not receive any more doxorubicin because of her increased risk of cardiotoxicity.
Patient Suitability for Chemotherapy Assessment
4a. Mrs ABA was due for 2nd cycle Docetaxel on 11 May 2010. However her FBC results showed that her hemoglobin was 8g/dL.
a. What would be the suitable treatment for her condition? (2m)
Administer blood transfusion before proceeding with chemotherapy
Continue with chemotherapy as scheduled
Increase the dose of Docetaxel
Start iron supplementation only
Should the docetaxel dose be reduced?
Yes, the docetaxel dose should be reduced.
No, the docetaxel dose should not be reduced.
The docetaxel dose should be increased.
The docetaxel dose should be reduce to 20% of total dose
Name the cytotoxic drug that causes the following major toxicity? a. Cardiotoxicity b. Pulmonary toxicity c. Palmar plantar erythemathosis d. Nephrotoxicity e. Neurotoxicity
a. Doxorubicin
b. Bleomycin
c. Capecitabine
d. Cisplatin
e. Vincristine
a. Methotrexate.
b. Pemetrexed
c. Capecitabine
d. Carboplatin
e. Vincristine
a. Fluorouracil
b. Cyclophosphamide
c. Capecitabine
d. Epirubicin
e. Vincristine
a. Docetaxel
b. Trastuzumab
c. Capecitabine
d. Oxaliplatin
e. Vincristine
When is mesna used? How does mesna works to prevent toxicity?
Mesna is used with cyclophosphamide/ifosfamide to prevent hemorrhagic cystitis by binding acrolein.
Mesna is used to treat hypertension by blocking angiotensin receptors.
Mesna is used as an antibiotic to prevent bacterial infections.
Mesna is used to enhance the effects of chemotherapy by increasing drug absorption.
Calculate the carboplatin dose in mg for the following patients: Carboplatin AUC 5, Male, 50 years old, 66kg, serum creatinine: 106umol/L
470MG
500MG
750MG
480MG
Calculate the carboplatin dose in mg for the following patients: Carboplatin AUC 5, Female, 25 years old, 104kg, serum creatinine: 86umol/L
855MG
900MG
750MG
800MG
The following regimens are used to treat what cancer?
a. FOLFIRI
b. AC
c. BEP
a. Colorectal cancer
b. Breast cancer
c. Germ cell tumour
a. Lung cancer
b. Breast cancer
c. Cervival cancer
a. Endometrial cancer
b. Breast cancer
c. Bone cancer
a. Colorectal cancer
b. Breast Cancer
c. Lymphoma
'Lifetime Cumulative Dose' refers to:
the total amount of a drug (or radiation exposure) that a patient has received over their entire life
The dose received in a single exposure event.
The average dose received per year.
The maximum dose allowed by regulations.
Name 2 drugs that have lifetime cumulative dose.
Doxorubicin, Bleomycin
Paracetamol, Ibuprofen
Amoxicillin, Metformin
Cetirizine, Loratadine
The maximum dose for vincristine: __________________________ (1m)
2 mg per dose
5 mg per dose
10 mg per dose
0.5 mg per dose
Vincristine cannot be administered intrathecally because:
it causes severe neurotoxicity and can be fatal
it is ineffective when given intrathecally
it causes severe gastrointestinal irritation
it leads to rapid renal failure
J.S. is a 60-year-old woman who was recently diagnosed with non-small cell lung cancer. Her oncologist wishes to use cisplatin 100 mg/m2 on days 1 and 29 and then every 6 weeks, plus vinorelbine 30 mg/m2 weekly for 6 weeks, as her chemotherapy regimen. Which one of the following is an appropriate antiemetic regimen for preventing acute emesis on day 1?
Aprepitant plus granisetron plus dexamethasone.
Aprepitant plus prochlorperazine plus dexamethasone.
Aprepitant plus granisetron plus ondansetron.
Lorazepam plus ondansetron plus metoclopramide.
