Free Printable Quiz on Bioavailability and Drug Metabolism

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Worksheets

Quiz on Bioavailability and Drug Metabolism

Total questions: 20

Worksheet time: 10mins

Name

Class

Date

1.

Bioavailability refers to:

a)

Fraction of drug excreted

b)

Proportion reaching systemic circulation

c)

Rate of metabolism

d)

Extent of protein binding

2.

Oral drugs have reduced bioavailability due to:

a)

Rapid IV entry

b)

First-pass metabolism

c)

High solubility

d)

Absence of enzymes

3.

First-pass metabolism mainly occurs in:

a)

Kidney

b)

Liver

c)

Spleen

d)

Lungs

4.

Drug with highest first-pass metabolism:

a)

Morphine

b)

Diazepam

c)

Gentamicin

d)

Heparin

5.

Factor increasing bioavailability:

a)

High first-pass metabolism

b)

Poor lipid solubility

c)

No hepatic metabolism

d)

Decreased absorption

6.

Absolute bioavailability compares:

a)

Oral vs IM

b)

IV vs oral

c)

IV vs rectal

d)

SC vs IM

7.

Bioavailability of IV drugs is:

a)

<100%

b)

50%

c)

Variable

d)

100%

8.

Apparent volume of distribution (Vd) is:

a)

Actual body volume

b)

Imaginary volume for drug dilution

c)

Plasma volume only

d)

Interstitial fluid volume

9.

Large Vd indicates:

a)

Drug stays in plasma

b)

Extensive tissue binding

c)

Poor distribution

d)

High renal clearance

10.

Drug with low Vd:

a)

Heparin

b)

Chloroquine

c)

Digoxin

d)

Amiodarone

11.

Vd is used to calculate:

a)

Maintenance dose

b)

Loading dose

c)

Rate of elimination

d)

Infusion rate

12.

Plasma protein binding mainly involves:

a)

Globulins

b)

Lipoproteins

c)

Albumin

d)

Chylomicrons

13.

Highly protein-bound drugs:

a)

Have short duration

b)

Are rapidly excreted

c)

Have low free fraction

d)

Cannot interact with receptors

14.

Most significant in protein binding displacement:

a)

Weak acids

b)

Weak bases

c)

Gases

d)

Volatile agents

15.

Protein binding affects:

a)

Toxicity only

b)

Distribution only

c)

Clearance and distribution

d)

Bioavailability alone

16.

In hypoalbuminemia, free drug concentration:

a)

Decreases

b)

Remains same

c)

Increases

d)

Is unpredictable

17.

Warfarin displacement increases:

a)

Bleeding risk

b)

Diuresis

c)

Heart rate

d)

Metabolism

18.

Drugs with >90% protein binding:

a)

Have low Vd

b)

High Vd

c)

Short half-life

d)

No clinical effects

19.

Protein-bound fraction is:

a)

Filtered by kidney

b)

Not filtered by kidney

c)

Actively secreted

d)

Highly diffusible

20.

High Vd and low protein binding are features of:

a)

Hydrophilic drugs

b)

Plasma-restricted drugs

c)

Lipid-soluble drugs

d)

Large polar drugs

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