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Worksheetspharmaco
Total questions: 15
Worksheet time: 15mins
Concerning alkaloids, choose the wrong answer:
digoxin is a well-known alkaloid
insoluble in water
soluble in organic solvents
morphine is an alkaloid od opium
obtained from plant
Penicillin is not administered rectally because:
need a carrier transport
induces vomiting
destroys rectal mucosa
degraded by flora
none of the above
What happens after taking cimetidine and sulfurylureas together :
hypoglycemia
headache
bleeding
hypertriglyceridemia
increased gastric acidity
Concerning passive diffusion:
lipophilic molecules can cross the membrane
it needs a carrier protein
it increases with the increase in thickness of the membrane
Which of the following are the two modifying factors that contribute to why women have higher blood peak
concentrations of alcohol than men when consuming equivalent amounts?
Lower blood volume & increased hormones
Lower fat content & more gastric alcohol dehydrogenase (ADH)
Higher fat content & more gastric alcohol dehydrogenase (ADH)
Lower fat content & less gastric alcohol dehydrogenase (ADH)
Higher fat content & less gastric alcohol dehydrogenase (ADH)
Which of the following is the median effective dose, or the dose at which % of the individuals exhibit the specified quantal response?
LD50
ED50
EC50
TD50
T.I.
10- Warfarin (Coumadin) is given as a racemic mixture with the S enantiomer being four times more active than the R enantiomer. If the mixture of Warfarin given is 50 % S and 50% R, what is the potency compared to
100% R enantiomer solution?
4 R + 1 S = 1
4 R + 1 S = 1.5
4 R + 1 S = 2
4 R + 1 S = 2.5
4 R + 1 S = 4
What form of a drug is more lipid-soluble, and thus would remain trapped within a compartment where the pH does not favor the lipid-soluble form?
Strong acid (A-)
Weak acid (A-)
Neutral (AH and B)
Weak base (BH+)
Strong base (BH+)
12- If pH > pKa, the drug is ____; and if pH < pKa, the drug is ____. An unprotonated acid is ____ and a
protonated base is ____.
Protonated; Unprotonated; Charged; Charged
Protonated; Unprotonated; Neutral; Neutral
Unprotonated; Protonated; Charged; Charged
Unprotonated; Protonated; Neutral; Charged
A patient diagnosed with type 2 diabetes is administered an oral dose of 0.1 mg chloropropamide, an insulin secretagogue and weak acid with a pa of 5.0. What is the amount of this drug that could be absorbed from the stomach at pH 2.0?
a. 99.9 ug
b. 90 ug
c. 50 ug
d. 0.05 mg
e. 0.01 mg
A patient is in the hospital and is stable on digoxin 0.175 mg IV qd (daily). How much digoxin, in mg, would you need to give your patient orally, given that the bioavailability for oral digoxin tablets is 0.7?
a. 0.1225 mg
b. 0.25 mg
c. 0.875 mg
d. 1.67 mg
e. No change is necessary
One liter contains 1,000 mg of a drug. After one hour, 900 mg of the drug remains. What is the clearance?
a. 100 mL
b. 100 mL/hr
c. 1 mg/ml
d. 100 mg
e. 1 mg/sec
What is the correct order of bond strength, from strongest to weakest?
Van der Waals > Hydrogen > Ionic > Covalent
lonic > Covalent > Hydrogen > Van der Waals
Covalent > Hydrogen > Ionic > Van der Waals
Covalent > Ionic > Hydrogen > Van der Waals
Van der Waals > Hydrogen > Covalent > Ionic
Which of the following is the equilibrium dissociation constant, where the concentration of free drug is at half-maximal binding?
a. EC50
b. Emax
c. Kd
d. Bmax
e. LD50
A 55-year-old woman with heart failure is to be treated with a diuretic drug. Drugs X and Y have the same mechanism of diuretic action. Drug X in a dose of 5 mg produces the same magnitude of diuresis as 500 mg of drug Y. Which of the following statements best describe these results?
a. Drug Y is less efficacious than drug X?.
b. Drug X is about 100 times more potent than drug Y.
c. Toxicity of drug X is less than that of drug Y.
d. Drug X and Drug Y have a narrow therapeutic window.
e. All of the above statements are true.
