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Total questions: 30

Worksheet time: 15mins

Name
Class
Date
1.

The immune system is composed of two major subdivisions:

a)

Cellular and Humoral immunity

b)

Primary and Secondary immunity

c)

Innate (non-specific) and Adaptive (specific) immunity

d)

T cells and B cells

2.

A key characteristic of innate immunity is that:

a)

It is antigen specific

b)

It becomes more efficient with repeated exposure

c)

Its onset is immediate

d)

It demonstrates immunological memory

3.

Adaptive or acquired immunity is characterized by all of the following EXCEPT:

a)

It is inducible by a foreign antigen

b)

It is antigen specific

c)

It demonstrates immunological memory

d)

It is not efficient in eliminating pathogens

4.

When comparing innate and adaptive immunity, the feature of "Specificity" is:

a)

Present in both

b)

Non-specific in both

c)

Specific in Innate, Non-specific in Adaptive

d)

Non-specific in Innate, Specific in Adaptive

5.

Which components are specifically listed as anatomical barriers in innate immunity?

a)

Lysozyme and complement

b)

Monocytes and macrophages

c)

Skin and mucus membranes

d)

Lymphocytes and T and B cells

6.

Lymphocytes, T cells, and B cells comprise the components of which immune system subdivision?

a)

Innate immunity

b)

The Complement system

c)

Adaptive immunity

d)

The Myeloid system

7.

Which cell type typically forms 75% of peripheral blood lymphocytes?

a)

B-lymphocytes

b)

Natural Killer cells

c)

Myeloid cells

d)

T-lymphocytes

8.

T cell precursors must migrate to which organ for differentiation into types like CD4+ T helper cell and CD8+ pre-cytotoxic T cell?

a)

Bone marrow

b)

Spleen

c)

Lymph nodes

d)

Thymus

9.

The typical ratio of T helper to T cytotoxic cells is:

a)

1:1

b)

2:1

c)

1:3

d)

3:2

10.

B-lymphocytes become active cells, called plasma cells, which produce:

a)

Cytokines

b)

Phagocytes

c)

Antibodies or immunoglobulins (Ig)

d)

Defensins

11.

Natural Killer (NK) cells constitute what approximate percentage of peripheral blood lymphocytes?

a)

75%

b)

25%

c)

5%-10%

d)

Less than 1%

12.

The primary (central) lymphoid organs are the bone marrow and the:

a)

Spleen

b)

Lymph nodes

c)

Thymus

d)

Mucosal associated lymphoid tissue

13.

Secondary lymphoid organs, such as lymph nodes and the spleen, are described as the sites where:

a)

Blood cells are born

b)

T cells differentiate

c)

Antigens meet lymphocytes and activate them

d)

Plasma proteins are produced

14.

The Clonal selection theory suggests that activated lymphocytes express:

a)

Multiple types of receptors

b)

Both specific and non-specific receptors

c)

Only one specific type of receptor

d)

Receptors that are always non-specific

15.

Which component is considered a "chemical factor" barrier in innate immunity?

a)

Normal flora

b)

Movement of cilia

c)

Lysozyme and phospholipase

d)

Skin and mucus membranes

16.

Humoral barriers to infection are characterized by edema and the attraction of which cell type?

a)

B lymphocytes

b)

Phagocytic cells

c)

T lymphocytes

d)

Mast cells

17.

The Complement System is composed of plasma proteins that are produced primarily by:

a)

NK cells and B cells

b)

Phagocytic cells and fibroblasts

c)

Liver cells, macrophages and gut epithelial cells

d)

Blood proteins and enzymes

18.

Complement components C1 to C9 are involved in the classical pathway, which is initiated by the binding of C1 to:

a)

Antigen-antibody complex

b)

Surface microbial components

c)

Mannose-binding lectin

d)

C3 component

19.

The Lectin pathway is initiated by the binding of mannose-binding lectin (MBL) to:

a)

C1 component

b)

Bacterial surfaces

c)

Antigen-antibody complexes

d)

C3b

20.

Which complement pathway is initiated by microbes in the absence of antibody?

a)

Classical pathway

b)

Lectin pathway

c)

Alternative pathway

d)

All three pathways

21.

The final common step in all three complement activation pathways is the formation of the:

a)

C3 convertase

b)

C1 complex

c)

Membrane attack complex (MAC)

d)

C3b fragment

22.

The function of complement that involves coating bacteria to enhance phagocytosis is called:

a)

Chemotaxis

b)

Lysis

c)

Opsonization

d)

Immunological memory

23.

Phagocytic cells use Toll-like receptors (TLRs) to recognize broad molecules on the surface of:

a)

Activated T cells

b)

B cells

c)

Microorganisms

d)

Complement proteins

24.

The oxygen-dependent intracellular killing process produces which types of compounds?

a)

Lysozyme and elastase

b)

Hydrolase and defensins

c)

Superoxide anion and hydrogen peroxide

d)

E-2 and IFN-gamma

25.

What is the definition of an Epitope (antigenic determinant)?

a)

A substance that induces a specific immune response

b)

A small molecule that cannot induce an immune response

c)

The portion of the antigen that binds to an antibody or T cell receptor

d)

A protein added to delay antigen absorption

26.

Which factor related to immunogenicity dictates that a molecule must have a high molecular weight to be immunogenic?

a)

Foreignness

b)

Size (Molecular weight)

c)

Biological System

d)

Methods of administration

27.

Antigens that can directly stimulate B cells to produce antibody without the requirement for T cell help are called:

a)

T-dependent antigens

b)

Superantigens

c)

T-independent antigens

d)

Haptens

28.

T-independent antigens are often chemically composed of:

a)

Proteins

b)

Polysaccharides

c)

Lipids

d)

Nucleic acids

29.

A key difference between T-independent and T-dependent antigens is that T-independent antigens generally do not form:

a)

Antibodies

b)

T cells

c)

Immunoglobulins M

d)

Memory cells

30.

Superantigens activate T cells non-specifically by binding to the T cell receptor (TCR) and the MHC Class II molecule on the:

a)

T-cytotoxic cell

b)

Helper B cell

c)

Antigen Presenting Cell (APC)

d)

Endotoxin