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Total questions: 30
Worksheet time: 15mins
The immune system is composed of two major subdivisions:
Cellular and Humoral immunity
Primary and Secondary immunity
Innate (non-specific) and Adaptive (specific) immunity
T cells and B cells
A key characteristic of innate immunity is that:
It is antigen specific
It becomes more efficient with repeated exposure
Its onset is immediate
It demonstrates immunological memory
Adaptive or acquired immunity is characterized by all of the following EXCEPT:
It is inducible by a foreign antigen
It is antigen specific
It demonstrates immunological memory
It is not efficient in eliminating pathogens
When comparing innate and adaptive immunity, the feature of "Specificity" is:
Present in both
Non-specific in both
Specific in Innate, Non-specific in Adaptive
Non-specific in Innate, Specific in Adaptive
Which components are specifically listed as anatomical barriers in innate immunity?
Lysozyme and complement
Monocytes and macrophages
Skin and mucus membranes
Lymphocytes and T and B cells
Lymphocytes, T cells, and B cells comprise the components of which immune system subdivision?
Innate immunity
The Complement system
Adaptive immunity
The Myeloid system
Which cell type typically forms 75% of peripheral blood lymphocytes?
B-lymphocytes
Natural Killer cells
Myeloid cells
T-lymphocytes
T cell precursors must migrate to which organ for differentiation into types like CD4+ T helper cell and CD8+ pre-cytotoxic T cell?
Bone marrow
Spleen
Lymph nodes
Thymus
The typical ratio of T helper to T cytotoxic cells is:
1:1
2:1
1:3
3:2
B-lymphocytes become active cells, called plasma cells, which produce:
Cytokines
Phagocytes
Antibodies or immunoglobulins (Ig)
Defensins
Natural Killer (NK) cells constitute what approximate percentage of peripheral blood lymphocytes?
75%
25%
5%-10%
Less than 1%
The primary (central) lymphoid organs are the bone marrow and the:
Spleen
Lymph nodes
Thymus
Mucosal associated lymphoid tissue
Secondary lymphoid organs, such as lymph nodes and the spleen, are described as the sites where:
Blood cells are born
T cells differentiate
Antigens meet lymphocytes and activate them
Plasma proteins are produced
The Clonal selection theory suggests that activated lymphocytes express:
Multiple types of receptors
Both specific and non-specific receptors
Only one specific type of receptor
Receptors that are always non-specific
Which component is considered a "chemical factor" barrier in innate immunity?
Normal flora
Movement of cilia
Lysozyme and phospholipase
Skin and mucus membranes
Humoral barriers to infection are characterized by edema and the attraction of which cell type?
B lymphocytes
Phagocytic cells
T lymphocytes
Mast cells
The Complement System is composed of plasma proteins that are produced primarily by:
NK cells and B cells
Phagocytic cells and fibroblasts
Liver cells, macrophages and gut epithelial cells
Blood proteins and enzymes
Complement components C1 to C9 are involved in the classical pathway, which is initiated by the binding of C1 to:
Antigen-antibody complex
Surface microbial components
Mannose-binding lectin
C3 component
The Lectin pathway is initiated by the binding of mannose-binding lectin (MBL) to:
C1 component
Bacterial surfaces
Antigen-antibody complexes
C3b
Which complement pathway is initiated by microbes in the absence of antibody?
Classical pathway
Lectin pathway
Alternative pathway
All three pathways
The final common step in all three complement activation pathways is the formation of the:
C3 convertase
C1 complex
Membrane attack complex (MAC)
C3b fragment
The function of complement that involves coating bacteria to enhance phagocytosis is called:
Chemotaxis
Lysis
Opsonization
Immunological memory
Phagocytic cells use Toll-like receptors (TLRs) to recognize broad molecules on the surface of:
Activated T cells
B cells
Microorganisms
Complement proteins
The oxygen-dependent intracellular killing process produces which types of compounds?
Lysozyme and elastase
Hydrolase and defensins
Superoxide anion and hydrogen peroxide
E-2 and IFN-gamma
What is the definition of an Epitope (antigenic determinant)?
A substance that induces a specific immune response
A small molecule that cannot induce an immune response
The portion of the antigen that binds to an antibody or T cell receptor
A protein added to delay antigen absorption
Which factor related to immunogenicity dictates that a molecule must have a high molecular weight to be immunogenic?
Foreignness
Size (Molecular weight)
Biological System
Methods of administration
Antigens that can directly stimulate B cells to produce antibody without the requirement for T cell help are called:
T-dependent antigens
Superantigens
T-independent antigens
Haptens
T-independent antigens are often chemically composed of:
Proteins
Polysaccharides
Lipids
Nucleic acids
A key difference between T-independent and T-dependent antigens is that T-independent antigens generally do not form:
Antibodies
T cells
Immunoglobulins M
Memory cells
Superantigens activate T cells non-specifically by binding to the T cell receptor (TCR) and the MHC Class II molecule on the:
T-cytotoxic cell
Helper B cell
Antigen Presenting Cell (APC)
Endotoxin
