WorksheetsImmune Receptors Quiz
Total questions: 10
Worksheet time: 5mins
What happens if T-cell activation occurs without inhibitory brakes?
Enhanced immune response
Tissue damage and autoimmunity
Reduced cytokine production
Increased NK-cell activation
What is the role of Immune Stimulatory Receptors (ISRs) in immune checkpoint molecules?
They prevent cell activation and maintain homeostasis.
They induce cell activation and effector activities.
They inhibit activated cells to return to quiescence.
They induce apoptosis in cells.
What process does CTLA-4 induce to weaken the co-stimulatory signaling of CD28?
Ligand phosphorylation.
Trans-endocytosis of CD80/CD86.
Direct activation of PI3-K.
Deactivation of TCR.
How does ligand-mediated ubiquitination interfere with TCR signaling?
By cleaving the extracellular domain of LAG-3.
By exposing signaling domains that disrupt the connection between CD4 or CD8 and Lck.
By activating TCR signaling directly.
By binding to MHC II and APC.
What is the expression status of inhibitory receptors in autoimmune conditions, and what clinical outcome does it correlate with?
High expression status; correlates with poor clinical outcome
Low expression status; correlates with favorable clinical outcome
High expression status; correlates with favorable clinical outcome
Low expression status; correlates with poor clinical outcome
What is the ligand associated with the immune checkpoint molecule OX40?
ICOS-L
OX40-L
GITR-L
CD70
What is the effect of checkpoint blockade on HCV viral load?
Increased HCV viral load
Decreased HCV viral load
No change in HCV viral load
Complete elimination of HCV viral load
Which inhibitory receptor is expressed in Tuberculosis infection?
PD-1
TIM-3
LAG-3
TIGIT
Which molecule competes with CD28 for CD80/86 in autoimmune diseases?
CTLA4-Ig (abatacept)
TCR
MHC
APC
What is the primary function of bispecific antibodies (bsAb)?
Targeting inhibitory receptors
Activating immune cells
Neutralizing toxins
Enhancing antibody production
