WorksheetsHEMA2-22
Total questions: 124
Worksheet time: 1hrs 2mins
Name
Class
Date
1.
Where are most coagulation factors produced?
a)
Spleen
b)
Liver
c)
Bone marrow
d)
Lymph nodes
2.
Factor VIII is produced in several tissues, but the major production site is the:
a)
Spleen
b)
Liver
c)
Bone marrow
d)
Lymph nodes
3.
Which coagulation factors are NOT primarily produced in the liver?
a)
Factor II and VII
b)
Factor VIII and XII
c)
Factors III and IV
d)
Factor V and X
4.
Which cells produce the von Willebrand factor portion of VIII:vWF?
a)
Hepatocytes
b)
Megakaryocytes and endothelial cells
c)
Neutrophils and macrophages
d)
Kupffer cells
5.
In liver disease, which coagulation factors typically increase?
a)
Factors II, V
b)
Factors VII, IX
c)
Factors XII, XIII
d)
Factors I and VIII
6.
Which coagulation factor has the shortest half-life?
a)
Factor IX
b)
Factor X
c)
Factor VII
d)
Factor V
7.
Because Factor VII has the shortest half-life, acute liver dysfunction will cause an early decrease in:
a)
aPTT
b)
PT
c)
TT
d)
BT
8.
PT is a good test to assess acute liver function because:
a)
Factor VII is part of the extrinsic pathway
b)
It evaluates platelet function
c)
It measures intrinsic pathway
d)
It detects fibrinogen abnormalities only
9.
Most coagulation factor deficiencies are inherited in what pattern?
a)
X-linked dominant
b)
X-linked recessive
c)
Autosomal dominant
d)
Autosomal recessive
10.
Which factor deficiencies are inherited as X-linked recessive?
a)
Factors II and V
b)
Factors VIII and IX
c)
Factors XI and XIII
d)
Factor VII only
11.
Fibrinogen
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
12.
♦ Most concentrated of all the plasma procoagulants
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
13.
Essential for platelet aggregation (links activated platelets through their GP IIb/IIIa platelet fibrinogen receptor)
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
14.
Platelet alpha granules absorb, transport and release abundant fibrinogen.
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
15.
Increases approximately 10 mg/dL per decade in the elderly
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
16.
● Mol. Weight (Daltons): 340,000
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
17.
Prothrombin
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
18.
Mol. Weight (Daltons): 71, 600
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
19.
Tissue Factor
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
20.
Thrombokinase
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
21.
Mol. Weight (Daltons): 44,000
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
22.
Mean plasma concentration: None
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
23.
Calcium ions
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
24.
Mol. Weight (Daltons): 40
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
25.
Half-life (hours): N/A
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
26.
Half-life (hours): insoluble
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
27.
Tissue Thromboplastin
a)
Factor I
b)
Factor II
c)
Factor III
d)
Factor IV
28.
Fibrinogen increases approximately ___ per decade in the elderly
a)
10 mg/dL
b)
100 mg/dL
c)
50 mg/dL
d)
20 mg/dL
29.
♦ If fibrinogen level is _____________________, PT and aPTT will be prolonged.
a)
10 mg/dL
b)
100 mg/dL
c)
50 mg/dL
d)
20 mg/dL
30.
♦ If fibrinogen level is <100 mg/dL, PT and aPTT will be _______.
a)
Shortened
b)
Prolonged
c)
Either
d)
Neither
31.
Proaccelerin
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
32.
Labile Factor
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
33.
Thrombogen
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
34.
Factor ___ Leiden = mutant factor ___ (Dutch investigators from the city of Leiden first described this mutation)
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
35.
Mol. Weight (Daltons): 330,000
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
36.
inactivated by protein C-protein S complex.
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
37.
Proconvertin
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
38.
Stable Factor
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
39.
Mol. Weight (Daltons): 50,000
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
40.
Has the shortest half-life (6hrs)
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
41.
First coagulation factor to be affected by warfarin therapy
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
42.
Deficiency of this factor is called Owren's disease or parahemophilia
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
43.
Antihemophilic
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
44.
Factor A (AHF-A)
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
45.
Antihemophilic globulin (AHG)
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
46.
Mol. Weight (Daltons): 330,000
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
47.
Free factor ___ is unstable in plasma (it circulates bound to vWF). During coagulation, thrombin cleaves factor ____ from vWF and activates it.
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
48.
Deficiency of this factor is called Hemophilia A or Classic hemophilia
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
49.
Largest molecule in the human plasma
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
50.
has receptor sites for BOTH platelets and collagen (helps to bind platelets to exposed subendothelial collagen during platelet adhesion).
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
51.
Mol. Weight (Daltons): 600,000 to 20,000,000
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
52.
GP Ib/IX/V - primary platelet surface receptor for ___
a)
Factor V
b)
Factor VII
c)
Factor VIII
d)
vWF
53.
Deficiency is called hemophilia B or Christmas disease
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
54.
Christmas Factor
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
55.
Antihemophilic
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
56.
Plasma Thromboplastin Component (PTC)
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
57.
Mol. Weight (Daltons): 57,000
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
58.
Stuart-Prower Factor
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
59.
Mol. Weight (Daltons): 58,800
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
60.
Antihemophilic Factor C (AHF-C)
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
61.
Plasma Thromboplastin Antecedent (PTA)
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
62.
Deficiency is called Hemophilia C or Rosenthal syndrome
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
63.
>50% of cases are seen in Ashkenazi Jews
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
64.
Mol. Weight (Daltons): 143,000
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
65.
Hageman Factor
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
66.
Glass Factor
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
67.
Contact Factor
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
68.
Deficiency of this factor has NO bleeding tendency but it has thrombotic tendency
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
69.
Mol. Weight (Daltons): 84,000
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
70.
Factor B (AHF-B)
a)
Factor IX
b)
Factor X
c)
Factor XI
d)
Factor XII
71.
Fibrin Stabilizing Factor
a)
Factor XIII
b)
PK
c)
HMWK
72.
Laki-Lorand Factor
a)
Factor XIII
b)
PK
c)
HMWK
73.
Mol. Weight (Daltons): 320,000
a)
Factor XIII
b)
PK
c)
HMWK
74.
To detect this factor deficiency, one may use 5M Urea Clot Solubility test, also known as Duckert's test
a)
Factor XIII
b)
PK
c)
HMWK
75.
Prekallikrein
a)
Factor XIII
b)
PK
c)
HMWK
76.
aka: Fletcher Factor
a)
Factor XIII
b)
PK
c)
HMWK
77.
Mol. Weight (Daltons): 85,000
a)
Factor XIII
b)
PK
c)
HMWK
78.
High-molecular-weight Kininogen
a)
Factor XIII
b)
PK
c)
HMWK
79.
Flaujeac Factor
a)
Factor XIII
b)
PK
c)
HMWK
80.
What factor becomes deficient early in liver disease, and what assay does its deficiency prolong?
a)
Prothrombin deficiency, the PT
b)
Factor VII deficiency, the PT
c)
FVIII deficiency, the PTT
d)
Factor IX deficiency, the PTT
81.
Mol. Weight (Daltons): 120,000
a)
Factor XIII
b)
PK
c)
HMWK
82.
Fitzgerald Factor
a)
Factor XIII
b)
PK
c)
HMWK
83.
Williams Factor
a)
Factor XIII
b)
PK
c)
HMWK
84.
Reid Factor
a)
Factor XIII
b)
PK
c)
HMWK
85.
Fibrinase
a)
Factor XIII
b)
PK
c)
HMWK
86.
What is the mean plasma concentration of factor VIII?
a)
None
b)
0.01 mg/dL
c)
0.05 mg/dL
d)
1 mg/dL
e)
8 to 10 mg/dL
87.
What is the mean plasma concentration of factor VII?
a)
None
b)
0.01 mg/dL
c)
0.05 mg/dL
d)
1 mg/dL
e)
8 to 10 mg/dL
88.
What is the mean plasma concentration of factor V?
a)
None
b)
0.01 mg/dL
c)
0.05 mg/dL
d)
1 mg/dL
e)
8 to 10 mg/dL
89.
What is the mean plasma concentration of factor IV?
a)
None
b)
0.01 mg/dL
c)
0.05 mg/dL
d)
1 mg/dL
e)
8 to 10 mg/dL
90.
What is the mean plasma concentration of factor III?
a)
None
b)
0.01 mg/dL
c)
0.05 mg/dL
d)
1 mg/dL
e)
8 to 10 mg/dL
91.
What is the mean plasma concentration of vWF?
a)
None
b)
0.01 mg/dL
c)
0.05 mg/dL
d)
1 mg/dL
e)
8 to 10 mg/dL
92.
What is the mean plasma concentration of Factor X?
a)
None
b)
0.01 mg/dL
c)
0.05 mg/dL
d)
1 mg/dL
e)
8 to 10 mg/dL
93.
What is the mean plasma concentration of HMWK?
a)
0.3 mg/dL
b)
0.5 mg/dL
c)
2 mg/dL
d)
3 mg/dL
e)
5 mg/dL
94.
What is the mean plasma concentration of Factor XIII?
a)
0.3 mg/dL
b)
0.5 mg/dL
c)
2 mg/dL
d)
3 mg/dL
e)
5 mg/dL
95.
What is the mean plasma concentration of Factor XII?
a)
0.3 mg/dL
b)
0.5 mg/dL
c)
2 mg/dL
d)
3 mg/dL
e)
5 mg/dL
96.
What is the mean plasma concentration of Factor XI?
a)
0.3 mg/dL
b)
0.5 mg/dL
c)
2 mg/dL
d)
3 mg/dL
e)
5 mg/dL
97.
What is the mean plasma concentration of Factor IX?
a)
0.3 mg/dL
b)
0.5 mg/dL
c)
2 mg/dL
d)
3 mg/dL
e)
5 mg/dL
98.
What is the mean plasma concentration of Factor I?
a)
35 to 50 ug/mL
b)
200 to 400 mg/dL
99.
What is the mean plasma concentration of PK?
a)
35 to 50 ug/mL
b)
200 to 400 mg/dL
100.
What is the half-life of factor II (Prothrombin)?
a)
6 hours
b)
12 hours
c)
24 hours
d)
35 hours
e)
60 hours
101.
What is the half-life of factor V Proaccelerin/ Labile Factor/ Thrombogen?
a)
6 hours
b)
12 hours
c)
24 hours
d)
35 hours
e)
60 hours
102.
What is the half-life of factor VII Proconvertin/ Stable Factor?
a)
6 hours
b)
12 hours
c)
24 hours
d)
35 hours
e)
60 hours
103.
What is the half-life of factor VIII Antihemophilic Factor A (AHF-A)/ Antihemophilic globulin (AHG)?
a)
6 hours
b)
12 hours
c)
24 hours
d)
35 hours
e)
60 hours
104.
What is the half-life of vWF?
a)
6 hours
b)
12 hours
c)
24 hours
d)
35 hours
e)
60 hours
105.
What is the half-life of Factor IX?
a)
6 hours
b)
12 hours
c)
24 hours
d)
35 hours
e)
60 hours
106.
What is the half-life of PK?
a)
6 hours
b)
12 hours
c)
24 hours
d)
35 hours
e)
60 hours
107.
What is the half-life of Factor I (Fibrinogen)?
a)
48 to 52 hours
b)
48 to 70 hours
c)
48 to 84 hours
d)
100 to 150 hours
e)
150 hours
108.
What is the half-life of Factor X (Stuart-Prower Factor)?
a)
48 to 52 hours
b)
48 to 70 hours
c)
48 to 84 hours
d)
100 to 150 hours
e)
150 hours
109.
What is the half-life of Factor XI Antihemophilic Factor C (AHF-C)/ Plasma Thromboplastin Antecedent (PTA)?
a)
48 to 52 hours
b)
48 to 70 hours
c)
48 to 84 hours
d)
100 to 150 hours
e)
150 hours
110.
What is the half-life of Factor XII Hageman Factor/ Glass Factor/ Contact Factor?
a)
48 to 52 hours
b)
48 to 70 hours
c)
48 to 84 hours
d)
100 to 150 hours
e)
150 hours
111.
What is the half-life of Factor XIII Fibrin Stabilizing Factor/ Fibrinase/ Laki-Lorand Factor?
a)
48 to 52 hours
b)
48 to 70 hours
c)
48 to 84 hours
d)
100 to 150 hours
e)
150 hours
112.
What is the half-life of HMWK?
a)
156 hours
b)
100 hours
c)
Either
d)
Neither
113.
refers to procoagulant portion
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
114.
measured by standard Factor VIII assays and APTT
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
115.
markedly decreased in Hemophilia A
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
116.
refers to the antigenic properties
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
117.
measured by immunoassays
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
118.
refers to the portion responsible for platelet aggregation in the presence of ristocetin
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
119.
termed as ristocetin cofactor
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
120.
also termed the von Willebrand factor
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
121.
required for normal platelet adhesion
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
122.
antigenic portion of the von Willebrand factor
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
123.
was previously termed Factor VIII related antigen (VIIIR:Ag)
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
124.
measured by immunoassays
a)
Factor VIII, Factor VIIIC, Factor VIII:C
b)
Factor VIII: Ag
c)
Factor VIIIR:RCo
d)
Factor VIII:vWF
e)
vWF:Ag
100 %
