WorksheetsAutonomic Pharmacology Worksheet (Transcribed)
Total questions: 20
Worksheet time: 10mins
Which muscarinic receptor subtype predominantly inhibits cardiac function?
M1
M2
M3
M4
A 50-year-old man on propranolol for migraine presents with severe bradycardia (35/min) and hypotension. Which medication can directly increase heart rate by increasing intracellular cAMP without acting on β-receptors?
Isoproterenol
Dopamine
Glucagon
Epinephrine
Which of the following drug is MOST selective for β3 receptors?
Mirabegron
Dobutamine
Isoproterenol
Terbutaline
A 26-year-old woman with asthma develops sudden wheezing during exercise and improves with her rescue inhaler. On which receptor does the drug primarily act?
α1
β1
β2
M3
The rate-limiting step in catecholamine synthesis is catalyzed by:
DOPA decarboxylase
Dopamine β-hydroxylase
Phenylethanolamine N-methyltransferase
Tyrosine hydroxylase
A 4-year-old child presents with flushed skin, dry mouth, dilated pupils, and confusion after accidental ingestion of some tablets present at home. Which class of drug is MOST likely responsible for these symptoms?
Muscarinic agonist
Muscarinic antagonist
α1 agonist
β-blocker
Which enzyme terminates the action of acetylcholine in the plasma?
Monoamine oxidase
Catechol-O-methyltransferase
Butyrylcholinesterase
Acetylcholinesterase
A 68-year-old man with benign prostatic hypertrophy is prescribed a drug that acts by relaxing prostatic smooth muscle with minimal effect on blood pressure. Which of the following is most likely?
Prazosin
Tamsulosin
Phenoxybenzamine
Atropine
Which adrenergic receptor subtype increases the release of renin from renal juxtaglomerular cells?
α1
α2
β1
β2
A 26-year-old farmer exposed to organophosphate pesticide presents with SLUDGE (acronym) symptoms and bradycardia. What drug should be administered immediately?
Pralidoxime
Atropine
Neostigmine
Pilocarpine
Which of the following drug causes bronchodilation by blocking M3 receptors?
Salbutamol
Ipratropium
Phenylephrine
Prazosin
Which of the following drug produces mydriasis without cycloplegia?
Atropine
Phenylephrine
Tropicamide
Pilocarpine
Reserpine lowers blood pressure by which of the following mechanism?
Blocking α1 receptors
Blocking β1 receptors
Inhibiting VMAT and preventing noradrenaline storage
Inhibiting MAO
A patient with myasthenia gravis worsens after increasing pyridostigmine dose, and edrophonium test worsens symptoms. What does this indicate?
Myasthenic crisis → increase dose
Cholinergic crisis → stop cholinesterase inhibitors
Cholinergic crisis → add atropine
Myasthenic crisis → give steroids
Which of the following drugs is a directly acting muscarinic agonist?
Atropine
Bethanechol
Neostigmine
Ipratropium
A patient with pheochromocytoma has to undergo surgery. Which of the following drug should be FIRST started in this patient?
Propranolol
Labetalol
Phenoxybenzamine
Atenolol
Which of the following drug inhibits dopamine β-hydroxylase?
Metyrosine
Reserpine
Carbidopa
Disulfiram
Stimulation of β1 receptors primarily has which of the following effects?
Vasodilation
Increased heart rate
Bronchodilation
Miosis
A COPD patient develops severe bronchoconstriction after he is prescribed a drug for treatment of essential tremor. Which of the following drug might be responsible?
Metoprolol
Propranolol
Nebivolol
Atenolol
Which of the following statement regarding ganglionic blockers is CORRECT?
They stimulate autonomic ganglia
They block muscarinic receptors
Their effect depends on dominant autonomic tone
They increase GI motility
