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WorksheetsNeoplasia and Cancer Quiz
Total questions: 20
Worksheet time: 10mins
Neoplasia is defined as
Reactive hyperplasia
Uncontrolled clonal proliferation of cells
Purely inflammatory process
Reversible growth
Term neoplasm literally means
New inflammation
New growth
Tumor only
Cancer only
Which feature best distinguishes neoplasia from hyperplasia?
Reversibility
Dependence on stimulus
Autonomous growth
Cell swelling
Six P’s of neoplasia include all EXCEPT
Progressive
Persists after stimulus
Proliferative
Parasitic
Painful
Neoplastic growth is said to be clonal because it arises from
Multiple cells
One transformed cell
Stem cells only
Inflammatory cells
Sustained proliferative signaling in cancer is commonly due to
Loss of tumor suppressor genes
Oncogene activation
Increased apoptosis
Immune evasion only
Which growth factor receptor is commonly amplified in breast cancer?
EGFR
HER2/neu
PDGFR
FGFR
Evading growth suppressors involves inactivation of
Oncogenes
Growth factor receptors
Tumor suppressor genes
Telomerase
Loss of p53 function primarily leads to
Cell cycle arrest only
Enhanced DNA repair
Failure of apoptosis and genomic instability
Reduced angiogenesis
Cancer cells resist apoptosis mainly by
Upregulating BAX
Downregulating BCL-2
Upregulating anti-apoptotic proteins
Activating caspases
Limitless replicative potential of cancer cells is due to activation of
Telomerase
Topoisomerase
DNA polymerase
RNA polymerase
Angiogenesis in tumors is mainly mediated by
EGF
TGF-β
VEGF
PDGF
Inducing angiogenesis allows tumors to
Reduce hypoxia only
Increase apoptosis
Grow beyond diffusion limits
Undergo differentiation
Ability of cancer cells to invade and metastasize requires loss of
E-cadherin
Integrins
MMPs
VEGF
Matrix metalloproteinases (MMPs) aid metastasis by
Increasing cell adhesion
Degrading extracellular matrix
Inhibiting angiogenesis
Inducing apoptosis
Reprogramming of energy metabolism in cancer refers to
Increased oxidative phosphorylation
Warburg effect with aerobic glycolysis
Reduced glucose uptake
Increased ketone use
Evading immune destruction is achieved by tumors via
Increased antigen presentation
PD-L1 expression
Enhanced MHC I expression
IL-2 secretion
Tumor-promoting inflammation contributes to cancer by
Suppressing mutations
Producing growth factors and ROS
Enhancing apoptosis
Reducing angiogenesis
Benign tumors are characterized by all EXCEPT
Encapsulation
Slow growth
Invasion and metastasis
Well-differentiated cells
Malignant tumors differ from benign tumors by presence of
Encapsulation
Anaplasia
Slow growth
Local compression
