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WorksheetsCNS Stimulants and cognition enhancers
Total questions: 13
Worksheet time: 7mins
Picrotoxin causes convulsions by:
Inhibiting glutamate release
Preventing chloride channel opening linked to GABA
Blocking sodium channels
Competitive inhibition of GABA-A receptor
Drug of choice for picrotoxin-induced convulsions is:
Phenobarbital is the optimal choice
Phenytoin is first-line therapy
Diazepam is the recommended agent
Lorazepam is preferred initially
Which scenario most supports choosing atomoxetine over methylphenidate for pediatric ADHD?
Need for rapid symptom control
Comorbid tic disorder present
Primary inattentive symptom pattern
History of stimulant misuse risk
Which monitoring plan is most appropriate during the first three months of methylphenidate therapy?
Daily serum methylphenidate levels
Quarterly MRI of prefrontal cortex
Weekly weight, appetite, and sleep logs
Monthly blood counts and liver enzymes
A caregiver asks why methylphenidate is preferred initially. Which rationale is most accurate?
Least risk of appetite suppression
No need for cardiovascular assessment
Superior efficacy with robust evidence
Longest duration with single dosing
Atomoxetine acts mainly by:
Enhancing dopamine release presynaptically
Blocking serotonin reuptake selectively
Antagonizing dopamine D2 receptors centrally
Inhibiting norepinephrine reuptake selectively
A patient with obstructive sleep apnoea asks for modafinil instead of using CPAP. Based on approvals, what is the most appropriate response?
Use modafinil as primary treatment
Consider modafinil for apnoea-related sleepiness
Avoid modafinil; treat apnoea directly
Switch to antidepressant therapy
A resident confuses modafinil’s approvals. Which pair correctly lists an approved and a not-approved use?
Narcolepsy and depression
Depression and insomnia
Sleep apnoea and narcolepsy
Shift-work disorder and insomnia
Which drug is a reversible acetylcholinesterase inhibitor indicated for mild-to-moderate Alzheimer’s disease?
Rivastigmine
Galantamine
Tacrine
Donepezil
A patient needs a cholinesterase inhibitor with simple daily dosing to improve adherence. Which choice fits best?
Galantamine immediate‑release with lunch and dinner
Memantine titrated three daily doses
Rivastigmine capsules taken morning and evening
Donepezil administered once each night
Which of the following is a common side effect of atomoxetine?
Weight gain
Dry mouth
Increased heart rate
Insomnia
What is the primary mechanism of action of donepezil in Alzheimer's disease?
Inhibiting serotonin reuptake
Enhancing dopamine release
Blocking NMDA receptors
Inhibiting acetylcholinesterase
A patient with ADHD is experiencing significant side effects from methylphenidate. Which alternative medication could be considered?
Clonidine
Guanfacine
Dexmethylphenidate
Venlafaxine
