WorksheetsCapsules preparation
Total questions: 15
Worksheet time: 8mins
In capsule dosage forms, what material typically makes up the shell that encloses the drug?
Polyethylene glycol matrix
Gelatin suitable for oral use
Cellulose acetate phthalate
Starch-based film coating
A hygroscopic drug is being considered for encapsulation. Which statement best explains a limitation of using standard gelatin capsules for this drug?
Gelatin shells absorb moisture readily
Gelatin shells resist water completely
Gelatin shells actively repel humidity
Gelatin shells enhance drug hydration
Which advantage of capsules most directly improves patient acceptance for drugs with unpleasant taste or odor?
Capsules are economical to produce
Capsules are attractive in appearance
Drug is enclosed in a tasteless shell
Capsules are easy to carry and handle
Based on the visuals, distinguish hard versus soft capsules by their typical contents.
Hard capsules often contain powders; soft capsules often contain liquids
Hard capsules often contain liquids; soft capsules often contain powders
Neither hard nor soft capsules contain discrete fills
Both hard and soft capsules primarily contain compressed tablets
In the diagrams showing capsule parts and powder filling, which component is designed to hold the drug powder before closure?
The rounded end with color stripe
The shorter domed cap segment
The longer cylindrical body shell
The external printed label area
Which statement best distinguishes Gelatin Type A from Gelatin Type B used in hard capsule shells?
Type B from skin, acid processed
Type A from skin, acid processed
Type B from plants, neutral processed
Type A from bone, alkaline processed
Hard gelatin shells typically maintain what moisture range to ensure appropriate mechanical properties?
16–20 percent moisture
12–16 percent moisture
8–12 percent moisture
4–8 percent moisture
Which additive functions primarily to make capsule shells non-translucent?
Plasticizers like glycerol
Preservatives like parabens
Colorants like iron oxides
Opaquing agents like titanium dioxide
Which statement best describes how gelatin used in hard capsules is produced?
By full hydrolysis of cellulose from plant fibers
By partial hydrolysis of collagen from animal tissues
By extraction of keratin from hair using alkaline wash
By polymerization of amino acids in stainless reactors
Identify the most appropriate pre-treatment for ossein derived from degreased crushed bone before gelatin extraction.
Enzymatic digestion with pepsin only
Acid treatment followed by lime treatment
Water wash followed by neutralization
Direct thermal extraction without pretreatment
A manufacturer needs Type A gelatin quickly from pigskins. Which processing sequence is most suitable?
Direct extraction, spray drying, milling
Lime treatment, prolonged aging, extraction
Oxidation, bleaching, solvent precipitation
Water wash, acid treatment, water wash
Which step ensures a uniform gelatin layer on capsule pins during early manufacture?
Stripping formed shells from the pins
Blast of cool air for surface drying
Spinning to distribute gelatin evenly
Dipping at controlled solution temperature
In the initial stage of hard gelatin capsule production, what is the typical temperature maintained for the dipping solution?
About 50 degrees Celsius
About 60 degrees Celsius
About 40 degrees Celsius
About 70 degrees Celsius
You observe incomplete film formation on several pins after dipping. Which immediate adjustment would most likely improve film uniformity without changing formulation?
Delay stripping until full drying
Raise spinning speed within safe limits
Extend the blast of cool air duration
Increase dipping solution temperature slightly
In the manufacturing cycle shown, what step occurs immediately before the cap and body are joined and ejected from the machine?
Dipping pins into gelatin solution
Trimming shell ends by stationary knives
Drying of gelatin shells on pins
Stripping shells from the pins
