WorksheetsPage 1
Total questions: 10
Worksheet time: 10mins
Choose the single best response: A middle-aged woman with diabetes mellitus is receiving antitubercular therapy including isoniazid and rifampicin. During treatment, she develops deep vein thrombosis (DVT) and is initiated on warfarin. Despite adequate dosing, her prothrombin time (PT/INR remains subtherapeutic). What is the most appropriate next step in management?
Increase the dose of warfarin
Replace warfarin with acenocoumarin
Discontinue rifampicin and substitute with ethambutol
Start low-molecular-weight heparin (LMWH)
Choose the single best response: Heparin therapy should be monitored with intermittent estimation of:
Bleeding time
Prothrombin time
aPTT
All of the above
Choose the single best response: The dose of aspirin used for anti-platelet effect is
75–150 mg per day
325–600 mg every 6–8 hours
3–5 g per day
1000–3000 mg per day
Choose the single best response: The anticoagulant of choice in pregnancy is:
Heparin
Warfarin
Dicumarol
Phenindione
Choose the single best response: Idarucizumab is the specific antidote for:
Rivaroxaban
Dabigatran
Apixaban
Edoxaban
A patient with burns and massive plasma loss is admitted to ICU. Which plasma expander is physiologically most ideal?
Albumin
Dextran
Gelatin polymer
Hydroxyethyl starch
The mechanism of action of clopidogrel is
ADP receptor inhibitor
Thromboxane A2 synthesis inhibitor
Glycoprotein IIb/IIIa inhibitor
Platelet serotonin receptor inhibitor
Which of these is a contraindication to the use of reteplase?
History of Myocardial infarction
Surgery in the past 5 years
Prior intracranial hemorrhage
Prior use of reteplase
Tranexamic acid is a specific antidote of:
Fibrinolytic drugs
Organophosphates
Barbiturates
Heparin
LMW heparin is preferred over unfractionated heparin because:
LMW heparin directly inhibit thrombin whereas unfractionated heparin acts via activation of antithrombin
LMW heparins have lesser risk of causing bleeding
LMW heparin can be given subcutaneously as well as orally
LMW heparin has consistent bioavailability
