WorksheetsSkeletal Muscle Relaxants
Total questions: 19
Worksheet time: 10mins
Tizanidine: Mechanism of action?
𝛂2 adrenergic receptor agonist
Dopamine receptor antagonist
Serotonin reuptake inhibitor
Calcium channel blocker
Cisatracurium, atracurium: Which class?
Depolarizing neuromuscular blockers
Non-depolarizing neuromuscular blockers
Muscle relaxants
Local anesthetics
Baclofen: Mechanism of action?
GABA-B receptor agonist
Dopamine receptor antagonist
Serotonin reuptake inhibitor
Norepinephrine reuptake inhibitor
Depolarizing neuromuscular blocking agents: Mechanism of action?
Mimics acetylcholine and acts as agonists at nicotinic receptors on the motor endplate, causing persistent depolarization that leads to initial muscle fasciculations followed by paralysis.
Inhibits acetylcholine release at the neuromuscular junction, preventing muscle contraction.
Blocks nicotinic receptors at the motor endplate, leading to muscle paralysis without depolarization.
Enhances the breakdown of acetylcholine, leading to reduced muscle activation.
Which reaction is responsible for producing laudanosine from certain non-depolarizing muscle relaxants?
Hofmann elimination
Hydrolysis
Transesterification
Decarboxylation
Malignant hyperthermia is a rare but life-threatening adverse reaction to which skeletal muscle relaxant?
Succinylcholine (a depolarizing neuromuscular blocker)
Rocuronium (a non-depolarizing neuromuscular blocker)
Vecuronium (a non-depolarizing neuromuscular blocker)
Atracurium (a non-depolarizing neuromuscular blocker)
What are the two main classifications of neuromuscular blockers?
1. Non-depolarizing neuromuscular blocking agents
2. Depolarizing neuromuscular blocking agents
3. Anticholinergic agents
4. Muscle relaxants
The drug that is used to reverse the effect of non-depolarizing neuromuscular blockers.
Neostigmine
Succinylcholine
Atracurium
Rocuronium
Among baclofen, diazepam, eperisone, tolperisone, and orphenadrine, which drug has the least sedative effect?
Baclofen
Diazepam
Tolperisone
Eperisone
List the antispasmodic drugs used for acute treatment
Cyclobenzaprine
Ibuprofen
Acetaminophen
Tolperisone
Name a depolarizing neuromuscular blocker
Pancuronium
Rocuronium
Succinylcholine
Vecuronium
Non-depolarizing neuromuscular blocking agents: Mechanism of action?
Inhibit the release of acetylcholine from the presynaptic neuron.
Competitively inhibit acetylcholine by binding to nicotinic receptors on the motor endplate, preventing depolarization and muscle contraction.
Enhance the effect of acetylcholine at the neuromuscular junction.
Block the reuptake of acetylcholine in the synaptic cleft.
Dantrolene: Mechanism of action?
Inhibits ryanodine receptors (RyR1) in skeletal muscle, ↓ Ca²⁺ release from the sarcoplasmic reticulum
Stimulates calcium release from the sarcoplasmic reticulum
Inhibits calcium uptake by the sarcoplasmic reticulum
Blocks sodium channels in skeletal muscle
A drug of choice for malignant hyperthermia
Dantrolene
Aspirin
Ibuprofen
Morphine
Spasmolytics used for chronic treatment that act on CNS
Baclofen
Tizanidine
Benzodiazepines (e.g. diazepam, clonazepam)
Carisoprodol
Botulinum toxin A: Mechanism of action?
Inhibits the reuptake of serotonin in the synaptic cleft.
Destroys SNAP-25, inhibiting acetylcholine release at the neuromuscular junction.
Blocks dopamine receptors in the brain.
Enhances the release of norepinephrine at the synapse.
Spasmolytics used for chronic treatment that act on muscle
Dantrolene
Botulinum toxin A
Cyclobenzaprine
Carisoprodol
Benzodiazepines: Mechanism of action?
Inhibition of serotonin reuptake
Positive allosteric modulator of GABA-A receptor
Antagonism of dopamine receptors
Blockade of NMDA receptors
Drug of choice for treating spasticity in patients with multiple sclerosis.
Baclofen
Dantrolene
Tizanidine
Carisoprodol
