WorksheetsLaboratory findings in Gatrointestinal System
Total questions: 15
Worksheet time: 8mins
A 32-year-old woman presents with jaundice and pruritus. Laboratory tests show ALP 650 U/L, GGT 420 U/L, mild elevation of ALT and AST, and conjugated hyperbilirubinemia.
The most likely diagnosis is:
Acute viral hepatitis
Hemolytic anemia
Cholestatic liver disease
hepatocellular carcinoma
A 45-year-old man with chronic hepatitis B shows HBeAg negative, anti-HBe positive, and low HBV DNA levels.
This phase is best described as:
Replicative phase
Non-replicative carrier phase
Acute hepatitis
Immune-tolerant phase
A patient presents with pale stools, dark urine, pruritus, and low urinary urobilinogen. Which jaundice type best fits this pattern?
Hemolytic jaundice with increased stercobilin
Hepatocellular jaundice with fluctuating pruritus
Obstructive jaundice with absent stercobilin
Physiologic jaundice with normal urine color
Which test best evaluates hepatocellular integrity rather than bile flow disturbances?
GGT, ALP, acid phosphatase, 5′-nucleotidase
Serum bilirubin and blood ammonia levels
Serum albumin concentration and cholinesterase activity
ALT (SGPT) and AST (SGOT) enzyme activities
Which scenario most likely elevates serum bilirubin while also allowing bilirubin to appear in urine?
Increased hemoglobin breakdown with normal hepatic conjugation
Reduced hepatic uptake with intact bile duct patency
Impaired hepatic conjugation producing unconjugated bilirubin
Obstructed bile ducts causing reflux of conjugated bilirubin
A patient with jaundice has AST/ALT ratio >1 with moderately elevated transaminases.
This laboratory pattern most strongly suggests:
Acute hepatitis A
Cholestasis
Chronic liver disease
Muscle injury
Which laboratory marker most directly assesses the liver’s ability to produce clotting factors?
Alkaline phosphatase level
Prothrombin Time measurement
Gamma-glutamyl transferase
Serum bilirubin concentration
Which laboratory finding supports the diagnosis of acute cholangitis?
Isolated ALT elevation
Leukocytosis, elevated ALP, and culture (+)
Low bilirubin
Normal liver enzymes
A patient presents with epigastric pain radiating to the back. Serum lipase is elevated and remains high for 10 days.
This finding supports the diagnosis of:
Pancreatic carcinoma
Acute pancreatitis
Gastric ulcer
Cholecystitis
A 25-year-old man presents with jaundice, fatigue, and dark urine for 5 days. Laboratory results show ALT 1,200 U/L, AST 980 U/L, total bilirubin 8 mg/dL, and positive IgM anti-HAV.
Which laboratory finding best explains the mechanism of jaundice in this patient?
Increased unconjugated bilirubin due to hemolysis
Extrahepatic bile duct obstruction
Hepatocellular injury impairing bilirubin conjugation and excretion
Genetic defect of bilirubin transport
In chronic hepatitis B infection, which serologic pattern best indicates transition from HBeAg positivity to reduced viral replication?
Rapid decline of HBsAg with rising ALT levels
Appearance of anti-HBe with persistent HBsAg
Early rise of anti-HCV followed by loss of HCV RNA
Disappearance of total anti-HBc and IgM anti-HBc
A patient with hepatocellular carcinoma is MOST likely to have elevated:
CA 19-9
CEA
AFP
PSA
The rapid urease test detects Helicobacter pylori by identifying:
Lactate production
Urea hydrolysis producing ammonia
Bacterial DNA
Antigen–antibody reaction
A patient with prolonged diarrhea develops dehydration.
Which laboratory test is MOST useful to assess severity and complications?
Stool culture
Serum electrolytes
Stool Fat Analysis
Serum bilirubin
Which laboratory test confirms active hepatitis C infection?
Anti-HCV
HCV RNA by RT-PCR
Serum ALT and AST
Serum albumin
