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WorksheetsTBL immuno 2526
Total questions: 30
Worksheet time: 15mins
Which of the following cells is the most important link between innate and adaptive immunity?
Neutrophil
NK cell
Dendritic cell
Eosinophil
Which molecule is primarily responsible for opsonisation of bacteria in early innate immune responses?
IgA
IgG
C3b
C5a
The part of an antigen that is specifically recognised by an antibody is known as the ...
Hinge region
Epitope
Paratope
Hapten
Which immunoglobulin class is most efficient at activating the classical complement pathway?
IgA
IgE
IgG
IgM
Which complement component is directly responsible for formation of the membrane attack complex (MAC)?
C3a
C3b
C5a
C5b
Deficiency of C1 inhibitor most commonly leads to ...
Recurrent bacterial infection
Autoimmune disease
Hereditary angioedema
Severe combined immunodeficiency
Agglutination reactions are most useful in the laboratory for detecting ...
soluble antigens
small haptens
particulate antigens
complement proteins
The zone in which maximal antigen–antibody lattice formation occurs is known as the ...
prozone
postzone
equivalence zone
saturation zone
Which cytokine is most strongly associated with fever and acute-phase response?
IL-2
IL-4
IL-10
TNF-α
IL-2 is essential primarily for
B-cell class switching
Activation and proliferation of T cells
Inhibition of macrophages
Induction of tolerance
Which event occurs first during phagocytosis?
Phagolysosome formation
Opsonisation
Chemotaxis
Intracellular killing
Defective oxidative burst in neutrophils is characteristic of ...
leukocyte adhesion deficiency
Chediak–Higashi syndrome
chronic granulomatous disease
DiGeorge syndrome
The primary role of HLA molecules is to ...
destroy infected cells
produce antibodies
present antigen to T lymphocytes
mediate phagocytosis
Exogenous antigens are typically presented via which pathway?
HLA class I to CD8⁺ T cells
HLA class II to CD4⁺ T cells
HLA class II to CD8⁺ T cells
HLA class I to CD4⁺ T cells
CD8⁺ cytotoxic T cells primarily eliminate infected cells by
Antibody-dependent cytotoxicity
Complement activation
Perforin and granzyme release
Phagocytosis
Which infection is best controlled by cell-mediated immunity?
Extracellular bacteria
Helminth infection
Viral infection
Encapsulated bacteria
The main function of plasma cells is to ...
present antigen
produce cytokines
kill infected cells
produce antibodies
Which immunoglobulin is most abundant in mucosal secretions?
IgA
IgE
IgG
IgM
Which immune mechanism is most important against extracellular bacteria?
Cytotoxic T cells
Antibody-mediated opsonisation
Type I interferons
Granuloma formation
Type I interferons mainly function to ...
Enhance antibody class switching
Inhibit viral replication
Suppress macrophages
Promote tolerance
Anaphylaxis is best classified as which type of hypersensitivity?
Type I
Type II
Type III
Type IV
Which hypersensitivity reaction is mediated by immune complexes?
Type I
Type II
Type III
Type IV
Central tolerance primarily occurs in the ...
Tonsils
Spleen
Lymph nodes
Thymus and bone marrow
Failure of self-tolerance may result in:
Immunodeficiency
Autoimmune disease
Graft rejection
Tumour immunity
Which immune cell plays a major role in early anti-tumour immunity without prior sensitisation?
CD4⁺ T cells
Cytotoxic T cells
B cells
NK cells
Tumour cells may evade immune responses by ...
increasing MHC expression
producing IL-2
downregulating HLA class I
activating complement
The most important antigen system in graft rejection is ...
ABO blood group
Rh system
HLA system
Complement system
Hyperacute graft rejection is mainly mediated by:
Cytotoxic T cells
NK cells
Pre-existing antibodies
Immune complexes
A child presents with recurrent Neisseria (gram negative bacteria with capsule) infections. Which immune defect is most likely?
IgA deficiency
C5–C9 deficiency
T-cell deficiency
IL-2 deficiency
A patient develops a delayed skin reaction 48 hours after a tuberculin test. This reaction is mediated mainly by:
IgE
Immune complexes
CD4⁺ Th1 cells
Cytotoxic T cells
