nonlinear kinetics review for relearning 2022

nonlinear kinetics

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What systems are potentially nonlinear?

Any system that requires energy and a carrier, enzyme, or receptor system that can be overwhelmed

Anything that follows Michealis-Menten

Open Ended

List any/all pkinetic systems that can be nonlinear

What systems have a nonlinearity?

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Multiple Choice

If a system follows linear kinetics, would you expect the Css,avg to increase when DR increases?

• Yes

• No

Css,avg

Multiple Choice

If a system follows linear kinetics, would you expect the AUC to decrease when Dose decreases?

• Yes

• No

AUC

Multiple Choice

If a system follows linear kinetics, would you expect the clearance to increase with increasing DR or Dose?

• Yes

• No

Clearance

Multiple Select

How can you tell that CL is decreasing with increasing DR?

• Css,avg will be increasing with increasing DR more than proportionally when given IV

• Css,avg will be decreasing with increasing DR more than proportionally when given IV

• t1/2 will be increasing as DR increases

What does CL determine?

Multiple Select

What could cause volume to change with increasing DR?

• nonlinear plasma protein binding

• nonlinear tissue protein binding

• nonlinear renal clearance

• nonlinear hepatic clearance

What determines V?

What does V determine?

Multiple Choice

What could cause bioavailability to change with increasing DR?

• nonlinear plasma protein binding

• nonlinear hepatic enzymes

• nonlinear renal clearance

What determines bioavailability?

What does F affect?