Neurocognitive Disorder

By NTUH

Neurocognitive Disorder

Alzheimer Disease

Multiple Choice

Which one of the following statements regarding Alzheimer disease(AD) is FALSE?

• There is no cure for AD.

• The most essential and often earliest clinical manifestation of AD is selective memory impairment.

• Plasma biomarkers for AD has been well established.

• AD may be inherited.

Multiple Choice

Which one of the following statements regarding Neurocognitive disorder(NCD) and AD is FALSE?

• In DSM-5, delirium is classified in NCD.

• The term “dementia” and NCD could be used interchangeably.

• Studies have found that patients decline 3-3.5 points on average on the MMSE each year.

• Regarding cholinesterase inhibitors, patients with dementia of mild to moderate severity may be the most likely to derive clinical benefit.

Vascular Dementia

Multiple Choice

下列關於Vascular Dementia 之敘述何者"錯誤"？

VCI = Vascular cognitive impairment

• Pure vascular dementia( dementia caused solely by vascular pathology) is common.

• As most patients with vascular dementia or VCI have

  small vessel disease rather than large vessel disease。

• A high burden of clinically unrecognized silent cerebrovascular disease can be sufficient to cause dementia。

• Vascular dementia is the second most common type of dementia.

Multiple Choice

下列關於Vascular dementia 之敘述何者"正確"?

• Patients with cognitive impairment and clinical or radiologic evidence of cerebrovascular pathology should be screened and treated for vascular risk factors.

• Cholinesterase inhibitor therapy should be initiated in patients with dementia diagnosed after a stroke, even if there is no progressive cognitive decline.

• Vascular dementia is a homogeneous disorder, so the prognosis is easily predictable.

• Patients of vascular dementia with a clinical ischemic stroke or transient ischemic attack should be treated with antithrombotic therapy regardless of stroke subtypes

Dementia with Lewy Bodies​

Multiple Choice

Which one was not core clinical features of DLB? (according to 4th consensus report of the DLB consortium)

• Fluctuating cognition with pronounced variations in attention and alertness.

• Recurrent visual hallucinations that are typically well formed and detailed.

• REM sleep behavior disorder, which may precede cognitive decline.

• Severe sensitivity to antipsychotic agents.

Multiple Select

Which feature(s) is/are more suggestive of DLB than other dementia? (>1 answers)

• SPECT: low dopaminergic activity in the striatum

• 23-I-MIBG myocardial scintigraphy: low uptake

• CT/MRI: medial temporal lobe structures atrophy

• FDG-PET: cingulate island sign

Frontotemporal Dementia​

Multiple Choice

Which one of the following is NOT included as one of the three clinical FTD syndromes and is typically associated with Alzheimer pathology?

• Behavior variant frontotemporal dementia

  (bvFTD)

• Nonfluent variant primary progressive aphasia

  (nvPPA)

• Semantic variant primary progressive aphasia

  (svPPA)

• Logopenic variant primary progressive aphasia

  (lvPPA)

Multiple Choice

There are FDA-approved disease-modifying treatments for FTD.

• True

• False

Neuropsychiatric Symptoms and Treatment

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Multiple Choice

治療Dementia病人psychotic symptoms最有證據力的藥物為？

• Quetiapine

• Aripiprazole

• Amisulpride

• Risperidone

Multiple Choice

關於dementia病人的depression，以下何者正確？

• 運動可有效改善憂鬱症狀

• 輕度至中度憂鬱的1st line therapy為SSRI

• 一旦使用antidepressants，停藥可能使憂鬱症狀惡化

• 不論有無dementia，depression在生物心理社會各方面仍類似