Immunological tolerance

What occurs during receptor editing?

• Change in the constant region of the heavy chain

• Change of the variable region of the light chain

• Change in disulphide bonds of the hinge region

• Change of both the heavy and light chains

What occurs during class switching?

• Change in the constant region of the heavy chain

• Change in both the heavy and light chains

• Change in the variable region of the light chain

• Change of the disulphide bonds of the hinge region

Where can we find IgD?

• B cells

• Plasma

• T cells

• Red blood cells

What does CD8+ normally attaches to, to provide the primary signal for cytotoxic T-cells to activate?

• MHCI

• MHCII

• TCR

• BCR

What is the characteristic molecule that identifies T-regs?

• FOXP3

• CD3

• CD8

• IgM

Do thymic epithelial cells have MHCI and MHCII at the same time?

• Yes

• No

Which is the general mechanism behind peripheral tolerance of T cells?

• Antigen sequestration

• Clonal anergy

• Clonal deletion

• T-regulatory cells