Hemoglobin & Oxygen Dissociation

State the chemical nature of hemoglobin

• Lipid

• Polysaccharide

• Polypeptide

• Triglyceride

State which cell contains hemoglobin

• Neutrophils

• Erythrocytes

• Lymphocytes

• Mast cells

Tags

NGSS.MS-LS1-3

Refers to the nature of blood plasma

• Consists mostly of water

• Nonpolar

• Hydrophobic

• Consists of solid particles such as blood cells

Which of the following is true about the structure of hemoglobin?

• Consists of 4 subunits called globular proteins

• Heme groups are hydrophilic regions

• Overall structure allows conformational changes

• Tertiary-structured protein

Describe the nature of movement of oxygen within the blood and surrounding tissues

• Moves down its electrochemical gradient

• Moves down its partial pressure

• Requires protein channels to diffuse across membranes

• Moves out into the alveolar space from the capillaries

This best describes positive cooperativity of hemoglobin

• As 1 O₂ binds to a heme group, it causes a sudden shift of polarity, attracting more O₂

• As 1 O₂ binds to a heme group, a conformational change occurs, making it more likely for additional O₂ to bind

• As 1 O₂ binds to a heme group, hemoglobin becomes slightly less hydrophilic

• As 1 O₂ binds to a globin group, the binding site of O₂ within the molecule becomes more exposed

Which is an accurate description of the overall environment between blood cells and surrounding tissues?

• The PO2 in the capillaries is lower than in surrounding tissues

• The PO2 in the capillaries is higher than in the surrounding tissues

State the curve of this graph

• Exponential

• Bell-shaped

• Parabolic

• Sigmoidal

In what point in the graph shows the condition of Hb within the alveoli?

• Point 1

• Point 2

• Point 3

What explains the steep slope of the curve?

• Binding of O₂ within the heme groups

• O₂ loading into hemoglobin

• Unloading of O₂ from hemoglobin

• Positive cooperativity