Pharm. Chapter 3

Which of the following is false regarding plasma membranes?

• They contain two layers of phospholipids.

• They contain cholesterol, carbohydrates, and proteins.

• Their phospholipids have a round head and one tail.

• Cholesterol and phospholipids are essential.

The primary site of gastrointestinal (GI) absorption of a drug is the:

• esophagus

• stomach

• small intestine

• large intestine

Which of the following is false regarding the GI tract and drug absorption?

• pH partitioning influences absorption.

• The presence of food in the stomach or intestine influences absorption.

• Protein solubility influences absorption.

• Blood flow influences absorption.

During pregnancy, the placenta may transfer drugs that are:

• ionized

• lipid-soluble

• water-soluble

• metabolized

An important mechanism that affects varying drug action and metabolism is the

• GI tract effect

• intestinal effect

• first-pass effect

• toxic drug action

Which of the following carries blood directly to the liver?

• A biochemical pathway

• Renal portal circulation

• Hepatic portal circulation

• Lymphatic portal circulation

Which of the following is NOT one of the three categories of tolerance?

• pharmacodynamic

• hydrophilic

• metabolic

• tachyphylaxis

Certain drugs are poorly distributed to the CNS because they:

• must be approved by the FDA

• are fat soluble

• pass through the blood-brain barrier

• are hepatotoxic

Faster drug excretion via the kidneys occurs by converting:

• lipid-soluble drugs into more water-soluble forms

• water-soluble drugs into more lipid-soluble forms

• the color of urine

• urea to amino acids

End-products of a drug occur in the:

• small intestine

• pancreas

• kidneys

• liver