Heme Biosynthesis

What is the rate limiting step of Heme Biosynthesis pathway?

• ALA Dehydratase

• ALA Synthase

• Uroporphyrinogen Decarboxylase

• Coproporphyrinogen Oxidase

What is the cofactor for the first step of Heme synthesis (the production of ALA)?

• Vitamin B5

• Vitamin B12

• Vitamin B6

• Vitamin B1

Which type of uroporphyrin is found in Heme structure?

• Type I

• Type II

• Type III

• Type IV

Which enzymes of the heme synthesis pathway is sensitive to lead in lead poisoning? (You can choose more than one box)

• ALA synthase

• ALA dehydratase

• Ferrochelatase

• Uroporphyrinogen decarboxylase

Which type of porphyria cause photosensitivity in the patient?

• ALA synthase deficiency

• ALA Dehydratase deficiency

• Acute intermittent porphyria

• Porphyria cutanea tarda