Beta lactam antibiotics

Which of the following is Beta lactam antibiotic

• Penicillins

• Cephalosporins

• Carbapenems

• Monobactam

• All of the above

The following are Extended spectrum Penicillins EXCEPT

• Amoxicillin

• Ampicillin

• Piperacillin

• Benzyl penicillin

Beta lactams mechanism of action

• Inhibits protein synthesis

• Inhibits cell wall synthesis

• Inhibits folic acid synthesis

• Inhibits DNA gyrase

Beta lactams mechanism of resistance

• Decreased permeability

• Destruction by beta lactamases

• Increased efflux

• Altered binding site

• All of the above

Spectrum for Beta lactams is

• Aerobic, anaerobic

• Gram positive, gram negative

• Cocci, bacilli

• All of the above

Beta lactams adverse effects is

• Hypersensitivity reactions

• Superinfection

• Jarisch herxheimer reaction

• All of the above

Which of the following is a Beta lactamase inhibitor

• Clavulanic acid

• Sulbactam

• Tazobactam

• All of the above

Advantages of combining Amoxicillin with Clavulanic acid

• Increased spectrum

• Synergistic

• Acts on previously resistant organism

• All of the above

The most problematic adverse effect of Beta lactams is

• Allergy

• Ototoxicity

• Nephrotoxicity

• Cardiotoxicity

Which is used in typhoid

• Third generation cephalosporin

• Penicillin G

• Penicillin V

• Benzathine Penicillin