Psychopharmacology Antipsychotic, Anxiolytic & Antiparkinson

Indications for Typical Antipsychotics

Side Effects of Typical Antipsychotics

• Extrapyramidal Symptoms

• Hyperprolactinemia

• Neuroleptic Malignant Syndrome

• Anti-HAM effects

Orthostatic hypotension due to

• Antihistamine

• Anti-a1-adrenergic

• Antimuscarinic

• Anticholinergic

Most 3 characteristic of Neuroleptic Malignant Syndrome (NMS)

• Fever

• Tremor

• Autonomic instability

• Rigidity

Mechanism of Action (MOA) of Atypical/ Second Generation Antipsychotics

• Block Dopamine (D2 Receptor)

• Block Norepinephrine Receptor

• Block Serotonin (5-HT2A Receptor)

Drug for Typical Antipsychotics

• Chlorpromazine (Thorazine)

• Clozapine (Clozaril)

• Thioridazine (Mellaril)

• Haloperidol (Haldol)

Side Effects of Atypical Antipsychotics

• Weight gain

• Anti-HAM effects

• Tardive dyskinesia

• Cardiac: QTc prolongation

• Neuroleptic Malignant Syndrome

Role of Anxiolytic is to relief anxiety & induce sleep (hypnotics)

• True

• Wrong

GABA causes

• Cl- influx into cell

• Hyperpolarization

• Depolarization

• Inhibit firing of neuronal activity

Anxiolytic Medication are

• SSRI

• Benzodiazepine

• Benzodiazepine-like substances (Z-drugs) - hypnotics

• Barbiturates

• 5HT1A agonists