Adv cell bio L05 L6 L07

Which of the following is an eg of g protein coupled receptor?

• Insulin receptor

• Adrenergic Receptor

• EGFR

• Calcium gated channel

Which of the following is an eg of receptor tyrosine kinase? you can pick > 1 ans

• Insulin receptor

• Adrenergic Receptor

• EGFR

• Calcium gated channel

Gαs stimulates adenylyl cyclase (AC) and increases cyclic AMP (cAMP) levels.

True or false?

• True

• False

Gαi family members activate phospholipase C (PLC), which cleaves phosphatidylinositol bisphosphate (PIP2) into diacylglycerol and inositol triphosphate (IP3). True or False

• False

• True

RTKs have how many transmembrane domain?

• 1

• 3

• 5

• 7

For RTKs, cis-autoinhibition occurs when ____?

• ligand binds to RTK

• there is no ligand

• when g protein is active

Which domains bind to RTKs after ligand binding? you can pick > 1 ans

• SH2 domain

• PTB domain

• ATP domain

activation of PLC by GPCRs to generate the two second messengers, which are? you can pick > 1 ans

• cAMP

• DAG

• IP3

• PIP2

most common calcium-binding motifs are? you can pick > 1 ans

• EF hands

• C2 domain

• SH2 domain

• ATP domain

Phosphorylation adds a phosphate group to ______, threonine, and tyrosine residues in a protein, changing their shapes, and activating or inactivating the protein

• Serine

• glycine

• alanine

• cysteine