PC- Antiemetic Drugs

Which of the following receptors is involved in N/V patho?

• H1 receptors

• M1 receptors

• D2 receptors

• 5HT3 receptors

• 5HT1 receptors

Which two receptors are expressed in the chemoreceptor trigger zone?

• chemoreceptors

• D2 receptors

• nicotinic receptors

• serotonin receptors

• muscarinic receptors

Which of the following is responsible for inducing motion sickness?

• vestibular

• chemoreceptor

• vomiting center

• central nervous system

GIT is rich in what type of receptors that induce vomiting upon stimulation?

• mechanoreceptors

• serotonin (5HT3)

• chemoreceptors

• H1 receptors

5HT3 antagonists are clinically used for which of the following?

• the prevention of acute chemotherapy-induced nausea and emesis

• the prevention of motion sickness

• the prevention and treatment of post-radiation N/V

Which of the following pharmaceutical preparations are antipsychotic agents that mediate antiemetic effect by blocking dopamine and muscarinic receptors?

• prochlorperazine

• promethazine

• clozapine

• droperidol

How does droperidol induce its antiemetic effect?

• blocking dopamine receptors

• blocking muscarinic receptors

• blocking H1 receptors

• all of these

Which of the following is NOT a dopamine receptor antagonist?

• domperidone

• risperidone

• diphenhydramine

• paliperidone

Which of the following is used in treatment for motion sickness?

• diphenhydramine

• dimenhydrinate

• domeperidone

• prochlorperazine

What is the MOA for dimenhydrinate?

• stimulate appetite and prevents vomiting through unknown mechanism

• D2 receptor antagonist and used mainly as pro kinetic agent

• blocking of H1 receptors and muscarinic receptors in the vestibular system

• block GABA receptors