Hemolytic Anemias

These inclusions which cannot be visualized on Wright-stained peripheral smears are often associated with:

• Pyruvate kinase deficiency

• Basophilic stippling

• Hgb H inclusion bodies

• G6PD

  deficiency

Which RBC morphology is formed as a result of Heinz bodies being pitted from the RBC in the spleen

• acanthocytes

• bite cells

• burr cells

• stomatocytes

Which of the following hemolytic disorders has RBCs that are especially sensitive to lysis by complement

• PNH

• PCH

• Hereditary spherocytosis

• G6PD deficiency

An anemia that manifests as decreased marrow cellularity, cytopenias in two cellular elements, and reticulocytopenia is termed

• Diamond Blackfan Anemia

• Aplastic anemia

• Sideroblastic anemia

• Hemolytic anemia

Individuals with Fanconi's anemia characteristically show

• intravascular hemolysis

• Increased Hgb F

• Ringed Sideroblasts

• Increased Hgb H

Which of the following red cell indices would most likely be found in Hereditary spherocytosis?

• MCV - 87

  MCH - 29.9

  MCHC- 34.5

• MCV - 65

  MCH - 27

  MCHC - 29.8

• MCV - 80.5

  MCH - 33.4

  MCHC - 39.0

• MCV 101

  MCH 30

  MCHC - 33.0

Choose the principal confirmation test for a diagnosis of hereditary spherocytosis

• autohemolysis test

• sucrose hemolysis test

• thermal stability test

• osmotic fragility test

Which of the following erythrocyte disorders is associated with abnormal membrane permeability?

• hereditary elliptocytosis

• hereditary stomatocytosis

• PNH

• hereditary spherocytosis

The osmotic fragility test determines whether a patient's RBCs are osmotically fragile by measuring the amount of hemolysis that occurs

• after a patients RBCs have been incubated in acidified serum

• when a patients RBCs have been incubated in various concentrations of hypotonic saline

• after a patients RBCs have been incubated in a sucrose solution

• after a patients RBCs have been incubated in their own serum for 48 hours

Immunophenotyping for a diagnosis of PNH uses the following monoclonal antibodies?

• CD55 and CD59

• CD11b and CD18

• CD33 and CD34

• CD56 and CD10