Myeloproliferative Disorders

Which management option is potentially curative in primary myelofibrosis?

• Chemotherapy

• Allogenic stem cell transplant

• Venesection

• Aspirin

Which investigation result would be diagnostic of acute myeloid leukaemia?

• White cell count >20 x 10⁹/L

• Presence of blast cells in the bone marrow

• ≥20% blasts on bone marrow aspiration

• Abnormal coagulation screen + a raised white cell count

The Philadelphia chromosome is the most commonly found cytogenetic abnormality in chronic myeloid leukaemia.

What type of abnormality is it?

• Deletion

• Translocation

• Duplication

• Inversion

In which myeloproliferative disorder would you be most likely to see poikilocytosis?

• Acute myeloid leukaemia

• Chronic myeloid leukaemia

• Myelofibrosis

Which condition would the presence of Auer rods be suggestive of?

• Acute myeloid leukaemia

• Chronic myeloid leukaemia

• Essential thrombocythaemia

• Polycythaemia vera

Which findings on a coagulation screen would be in keeping with disseminated intravascular coagulation?

• Low haemoglobin

• Prolonged prothrombin time

• Raised urea

• Raised INR

• Low fibrinogen

What is the most common leukaemia in adults?

• Acute myeloid leukaemia

• Chronic myeloid leukaemia

• Acute lymphocytic leukaemia

• Chronic lymphocytic leukaemia

For which type of leukaemia are tyrosine kinase inhibitors the mainstay of treatment?

• Acute lymphocytic leukaemia

• Chronic lymphocytic leukaemia

• Acute myeloid leukaemia

• Chronic myeloid leukaemia

Which test result would be required for the diagnosis of myelofibrosis?

• Bone marrow aspiration

• Bone marrow biopsy

• Peripheral blood smear

• Platelet count

How many phases does chronic myeloid leukaemia have?

• 1

• 2

• 3

• 4