Experimental Epidemiology

What is the purpose of randomization in an experimental study?

• 1. To ensure blinding of participants

• 1. To allocate participants into different groups based on their characteristics

• 1. To eliminate bias and confounding variables

• 1. To reduce the sample size required for the study

What is the purpose of blinding in an experimental study?

• 2. To prevent the researcher from being biased in data collection and analysis

• 1. To ensure participant confidentiality

• 1. To increase the generalizability of the study results

• 1. To improve participant recruitment for the study

Which of the following best describes the design of a crossover trial?

• 1. Participants are randomly assigned to different treatment groups.

• 1. Each participant receives all treatments in a specific sequence.

• 1. Participants are divided into two groups, one receiving treatment and the other receiving placebo.

• 1. Participants are observed for a long period to assess the development of outcomes.

What is a washout period in a crossover trial?

• 1. The time period during which participants are not receiving any treatment.

• 2. The time required for data analysis and reporting.

• 1. The duration of the entire study from recruitment to completion.

• 2. The time interval between different treatment periods.

Which statistical test is commonly used to analyze data from crossover trials?

• 1. Chi-square test

• 1. Independent t-test

• 1. Paired t-test

• 1. Analysis of variance (ANOVA)

What is the primary objective of a Phase I clinical trial?

• 1. To determine the safety and dosage range of an intervention

• 1. To compare the effectiveness of two different interventions

• 1. To assess the long-term outcomes of an intervention

• 1. To evaluate the feasibility of conducting a larger clinical trial

Write about various Phases in clinical trial