ACE Inhibitors

Availability:

T: 5 mg, 10 mg, 20 mg, 40 mg

Use:

HTN

Dosage Range (per day):

Initially, 10 mg/day. Usual dose: 20–80 mg once/d or divided bid.

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Benazepril

  (Lotensin)

• Captopril

  (Capoten)

Availability:

T: 12.5 mg, 25 mg, 50 mg, 100 mg

Use:

HTN, HF

Dosage Range (per day):

HTN: Initially, 12.5–25 mg 2–3 times/day. Usual dose: 50–100= mg 2 times/day.

HF: Initially, 6.25 mg 3 times/day. Target: 50 mg 3 times/day.

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Benazepril

  (Lotensin)

• Captopril

  (Capoten)

Availability:

T: 2.5 mg, 5 mg, 10 mg, 20 mg IV: 1.25 mg/m

Use:

HTN, HF

Dosage Range (per day):

HTN: Initially, 2.5–5 mg/day; may increase at 1–2 wk intervals.

Usual dose: 5–40 mg once/d or divided bid.

HF: Initially, 2.5 mg 2 times/day, may increase at 1–2 wk intervals.

Target: 20 mg/day in 1–2 divided doses.

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Enalapril

  (Vasotec)

• Fosinopril

  (Monopril)

Availability:

T: 10 mg, 20 mg, 40 mg

Use:

HTN, HF

Dosage Range (per day):

HTN: Initially, 10mg/day. Usual dose: 10–80 mg once/d.

HF: Initially, 5–10 mg/day.

Target: 10–40 mg/day.

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Enalapril

  (Vasotec)

• Fosinopril

  (Monopril)

Availability:

T: 2.5 mg, 5 mg, 10 mg, 20 mg, 40 mg

Use:

HTN, HF

Dosage Range (per day):

HTN: Initially, 5–10 mg/day. Usual dose: 10–40 mg/once/d.

HF: Initially, 2.5–5 mg/day. Target: 20–40 mg/day..

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Lisinopril

  (Prinivil,

  Zestril)

• Moexipril

  (Univasc)

Availability:

T: 7.5 mg, 15 mg

Use:

HTN

Dosage Range (per day):

HTN: Initially, 3.75–7.5 mg/day. Usual dose: 7.5–30 mg/day in 1–2 divided doses.

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Lisinopril

  (Prinivil,

  Zestril)

• Moexipril

  (Univasc)

Availability:

T: 2 mg, 4 mg, 6 mg

Use:

HTN

Dosage Range (per day):

HTN: Initially, 4 mg/day. May increase at 1–2 wk intervals. Usual dose: 4–8 mg once/d or divided bid.

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Perindopril

  (Aceon)

• Quinapril

  (Accupril)

Availability:

T: 5 mg, 10 mg, 20 mg, 40 mg

Use:

HTN, HF

Dosage Range (per day):

HTN: Initially, 10–20 mg once daily. Usual dose: 10–40 mg once/d or divided bid.

HF: Initially, 5 mg 2 times/day. Titrate to 20–40 mg/day in 2 divided doses.

Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Perindopril

  (Aceon)

• Quinapril

  (Accupril)

Availability:

C: 1.25 mg, 2.5 mg, 5 mg, 10 mg

Use:

HTN, HF

Dosage Range (per day):

HTN: Initially, 2.5 mg once daily. Usual dose: 2.5–20 mg once/d or divided bid.

HF: Initially, 1.25– 2.5 mg once daily.

Target: 10 mg once

daily. Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Ramipril

  (Altace)

• Trandolapril

  (Mavik)

Availability:

T: 1 mg, 2 mg, 4 mg

Use:

HTN, HF

Dosage Range (per day):

HTN: Initially, 1–2 mg once daily. Usual dose: 2–8 mg once/d or divided bid.

HF: Initially, 1 mg once daily. Target: 4 mg once daily.

daily. Frequent or Severe Side Effects:

Class Effects

Cough, hypotension, rash, acute renal failure (in pts with renal artery stenosis), angioedema, hyperkalemia, mild moderate loss of taste, hepatotoxicity, pancreatitis, Blood dyscrasias, Renal damage

• Ramipril

  (Altace)

• Trandolapril

  (Mavik)