rh typingzzz lb

Weak D

• Donor = Rh (+)

• Patient = Rh (+)

Weak D

• Donor = Rh (-)

• Patient = Rh (-)

Normal expression of D antigen

• DCE/dce

• Dce/dCe

Weakened expression of D antigen

• DCE/dce

• Dce/dCe

One or more parts of the D antigen is missing/altered

The anti-D made by individuals expressing partial D can cause:

• HDN

• Transfusion reactions

In general, Weak D (+) are Rh ______:

• Positive

• Negative

1939: Described a hemolytic transfusion reaction in an obstetrical patient.

• Levine

• Stetson

1940's: An antibody made by guinea pigs and rabbits when they were transfused with rhesus monkey RBCs

• Landsteiner

• Wiener

This antibody, which agglutinated 85 percent of human RBCs, was named