KOVAI Quiz

______amino acid substitutions are introduced to lower the IR binding & subsequently the IR mediated clearance.

• 1

• 2

• 3

• 4

Very strong reversible albumin binding is achieved by introducing a ______ at the C-terminal of B chain

• C-20 icosane fatty diacid

• C-18 icosane fatty diacid

• C-16 icosane fatty diacid

• C-22 icosane fatty diacid

In the subcutaneous tissue, insulin icodec is present in _____ form

• hexamer

• dihexamer

• multihexamer

t 1/2 of insulin icodec is ________

• 196 hours

• 168 hours

• 150 hours

• 225 hours

There is ______ excess of albumin binding sites in circulating albumin pool compared with insulin icodec serum conc.

• >2 fold

• >20 fold

• >200 fold

• >2000 fold

Icodec will be available in a stable _____ formulation

• 100 U/mL

• 200 U/mL

• 700 U/mL

• 300 U/mL

Significantly greater reduction in HbA1c was seen with insulin icodec in all of the insulin naive ONWARDS trials

• True

• False

Rates of combined level 2 or 3 hypoglycemia were < 1 event per PYE with icodec in the insulin naive ONWARDS trials

• True

• False

_______ is the longest trial in the ONWARDS development program

• ONWARDS 1

• ONWARDS 2

• ONWARDS 3

• ONWARDS 4

Significantly greater changes were seen in DTSQ satisfaction score for _______ in patients switched to icodec.

• Convenience

• Flexibility

• Willingness to continue treatment

• All of the above