Transplant Rejection Reactions Quiz

What is the mechanism of hyperacute rejection?

• CD8+ CTLs directly destroy graft

• Antibodies bind to endothelium and activate complement

• T-cells react against alloantigens

• Antidonor antibodies present in the circulation of the recipient

Which histopathological finding is associated with acute cellular rejection?

• Tubulointerstitial pattern with extensive interstitial and tubular inflammation

• Intimal thickening and vascular occlusion

• Cyanotic and mottled graft with pale white areas

• Glomerulopathy with duplication of basement membrane

What characterizes the vascular pattern in acute rejection?

• Interstitial fibrosis and tubular atrophy

• Focal thrombosis in small vessels

• Endotheliitis with swollen endothelial cells and lymphocytes

• Duplication of basement membrane

Which mechanism is involved in chronic rejection?

• Antidonor antibodies present in the circulation

• CD8+ CTLs directly destroy graft

• Antibodies bind to endothelium and activate complement

• T-cells react against alloantigens and secrete cytokines

What is a histopathological finding in chronic rejection?

• Inflammation of glomeruli and peritubular capillaries

• Acute fibrinoid necrosis of vessel walls

• Cyanotic and mottled graft with pale white areas

• Intimal thickening and vascular occlusion

Which of the following is a feature of acute antibody-mediated rejection?

• T-cells react against alloantigens and secrete cytokines

• Intimal thickening and vascular occlusion

• Activation of the antibody-dependent classical complement pathway

• Tubulointerstitial pattern with extensive interstitial inflammation