Medications for Exam 6

Organize these options into the right categories

Groups:

(a) Renal Dose Adjustment

,

(b) No Renal dose adjustment

• Valacyclovir

• Foscarnet

• baricitinib

• Cidofiver

• tociluzumab

• Famvir

• remdesivir

• molnupiravir

• Abreva

• docosanol

• dexamethasone

• penciclovir

• letermovir

• nirmatrelvir/ritonavir

• Valtrex

• valganciclovir

• acyclovir

• Famciclovir

• ganciclovir

Organize these options into the right categories

Groups:

(a) Renal Dose Adjustment

,

(b) No Renal Dose Adjustment

• baloxavir

• nirmatrelvir/ritonavir

• dexamethasone

• remdesivir

• oseltamivir

• zanamivir

• tocilizumab

• peramavir

• baricitinib

• molnupiravir

• foscarnet

• cidofivir

First line therapy for treatment and prevention of seasonal influenza

• oseltamivir

• zanamivir

• peramavir

• baloxavir

• amantadine

Treatment and prevention of seasonal influenza

• oseltamivir

• zanamivir

• peramavir

• baloxavir

• amantadine

Treatment of influenza in patients who are unable to take medications by mouth

• oseltamivir

• zanamivir

• peramavir

• baloxavir

• amantadine

Match the brand/generic

• Paxlovid

• Remdesivir

• Tamiflu

• baloxavir marboxil

• Relenza

• oseltamivir

• Veklury

• zanamivir

• Xofluza

• Nirmatrelvir / Ritonavir

match the characteristics

• docosanol

• Oral prodrug of penciclovir

• famciclovir

• Used only for episodic treatment of secondary herpes labialis

• acyclovir

• Oral bioavailability (10-30%) decreases with increasing doses

• penciclovir

• L-valyl ester of acyclovir; enhanced bioavailability (70%)

• valacyclovir

• Longer intracellular half-life but lower affinity for HSV DNA polymerase than acyclovir

match the characteristics

• foscarnet

• only effective against replicating virus

• cidofivir

• long intracellular half-life allows for weekly dosing

• dexamethasone

• Contains sulfobutyl ether beta-cyclodextrin sodium (SBECD) which accumulates in renal dysfunction; clinical significance unclear

• letermovir

• Not beneficial in outpatients or hospitalized patients who do not require supplemental oxygen

• remdesivir

• Intravenous vehicle hydroxypropyl betadex may accumulate in renal failure

match the characteristics

• baricitinib

• pharmacologic VTE prophylaxis should be given concomitantly

• tocilizumab

• Most used antiviral medication for prevention and treatment of influenza

• molnupiravir

• Preferred over XX for those with acute VTE, severe renal dysfunction, or unable to receive pharmacologic VTE prophylaxis

• nirmatrelvir / ritonavir

• Drug-drug interactions are a major concern and concomitant medications should be evaluated for interactions before prescribing

• oseltamivir

• Should not be used in pregnant patients due to concerns for mutagenesis

match the characteristics

• dexamethasone

• If a patient requires hospitalization after starting treatment, the full 5-day treatment course of ritonavir-boosted nirmatrelvir should be completed unless there are drug-drug interactions that preclude its use.

• baloxavir marboxil

• Only available as a topic dosage form

• nirmatrelvir / ritonavir

• Should not be prescribed after hospital discharge

• penciclovir

• contraindicated in patients on mechanical ventilation

• zanamivir

• Do not use in immunocompromised hosts, in patients hospitalized with influenza infection, pregnancy, or patients ≤ 5 years