Mechanism of Production & Renal Elimination of Creatinine

The video explains the formation and excretion of creatinine, a waste product from creatine. It details the role of creatine phosphate in ATP production during high-intensity exercise and the non-enzymatic degradation of creatine phosphate to creatinine. The transport of creatinine to the kidneys and its excretion in urine is discussed, along with the impact of exercise on creatinine formation. The video also highlights the diagnostic use of creatinine levels in detecting heart attacks.

What is the primary role of creatine phosphate in skeletal muscle?

• To provide a quick source of ATP during high-intensity exercise

• To store oxygen for muscle cells

• To act as a waste product in muscle metabolism

• To transport nutrients to muscle cells

How is creatinine formed from creatine phosphate?

• Through passive diffusion

• Via direct phosphorylation

• By a non-enzymatic cyclization process

• Through an enzymatic reaction

What characteristic of creatinine allows it to diffuse through the muscle cell membrane?

• Its large molecular size

• Its ionic charge

• Its cyclic structure and loss of phosphate

• Its hydrophilic nature

Which transporter is involved in moving creatinine into the proximal tubule of the nephron?

• SLC 22A2

• GLUT4

• Aquaporin

• Na+/K+ ATPase

What happens to the pH of muscle cells during high-intensity exercise?

• It increases due to ATP production

• It decreases due to hydrogen ion accumulation

• It remains constant

• It increases due to oxygen accumulation

Why is creatinine used as a diagnostic tool for myocardial infarction?

• It is a marker for low blood pressure

• It indicates high oxygen levels in the blood

• It shows elevated ATP levels

• It is released into the blood when heart cells rupture

What effect does increased acidity have on creatinine formation?

• It has no effect

• It speeds up the formation

• It slows down the formation

• It reverses the formation process