Acetyl-S-CoA Synthetase: Physiology, Biochemistry, and Mechanism

The video explains the conversion of acetate to acetyl CoA, highlighting the role of acetyl CoA synthetase. It discusses the toxic nature of acetate, the enzyme's mechanism, and the thermodynamic aspects of the reaction. The video also covers the biological significance of acetyl CoA in the TCA cycle and its role in biosynthesis, emphasizing the energy release and the importance of removing toxic acetate.

What is the primary role of acetyl CoA synthetase in the body?

• To convert acetate to acetyl CoA

• To convert acetyl CoA to citrate

• To convert acetaldehyde to acetate

• To convert ethanol to acetaldehyde

Why is acetate considered toxic in the body?

• It is easily excreted

• It is a byproduct of protein metabolism

• It causes headaches and hangovers

• It is a necessary nutrient

What is the significance of acetyl CoA in metabolic pathways?

• It is a precursor for glucose

• It is a waste product

• It is used in the TCA cycle

• It is a storage form of energy

What is the role of ATP in the conversion of acetate to acetyl CoA?

• It is a byproduct of the reaction

• It provides energy for the reaction

• It is not involved in the reaction

• It acts as a substrate

What type of intermediate is formed during the reaction mechanism?

• Hexavalent intermediate

• Pentavalent intermediate

• Bipyramidal intermediate

• Tetrahedral intermediate

What happens to the pyrophosphate released during the reaction?

• It is excreted from the body

• It is converted to ATP

• It is metabolized by inorganic pyrophosphatase

• It is stored in the cell

What is the final product of the reaction mechanism discussed?

• Citrate

• Ethanol

• Acetyl CoA

• Acetate

How does the body perceive ethanol produced by bacteria?

• As a nutrient

• As a foreign and potentially toxic substance

• As a source of energy

• As a waste product

What is a potential downside of the acetate to acetyl CoA conversion pathway?

• It does not produce any useful products

• It produces toxic byproducts

• It requires the use of ATP

• It is an inefficient process

What is the main benefit of converting acetate to acetyl CoA?

• It produces ethanol

• It generates energy

• It removes a toxic molecule and produces a useful one

• It stores energy for later use