Caffeine Demethylase Mechanism

The video discusses caffeine metabolism, highlighting its treatment as a toxin by the body. It explains the role of the liver and P-450 enzymes in caffeine detoxification, focusing on the demethylation process. The video also covers the radical mechanism involved in this process and concludes with a discussion on caffeine's effects and health benefits.

Why is caffeine considered a toxin by the body?

• Because it is not metabolized by the liver.

• Because it is beneficial in high doses.

• Because it can be lethal in large amounts.

• Because it is a synthetic compound.

What is the primary enzyme responsible for caffeine metabolism?

• CYP2C9

• CYP1A2

• CYP3A4

• CYP2D6

How many methyl groups does caffeine have?

• One

• Four

• Three

• Two

What happens to caffeine when it is demethylated twice?

• It becomes more active.

• It becomes toxic.

• It remains unchanged.

• It loses most of its activity.

What role does the heme coenzyme play in caffeine demethylation?

• It converts caffeine into a toxin.

• It acts as a substrate.

• It facilitates the radical mechanism.

• It inhibits the P-450 cycle.

What is a byproduct of caffeine metabolism?

• Methanol

• Ethanol

• Formaldehyde

• Acetaldehyde

What is the effect of moderate caffeine consumption?

• It causes heart attacks.

• It is beneficial for health.

• It has no effect.

• It shortens lifespan.