Aconitase 1

Aconitase 1

Assessment

Interactive Video

Science, Engineering, Chemistry

University

Hard

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This video explores the organic mechanism of the enzyme aconitase in the TCA cycle. It details the mechanistic steps, including proton transfer and elimination reactions, and highlights the stereochemical aspects of the reaction, such as anti periplanar orientation and anti addition. The video concludes with the formation of isocitrate, emphasizing its unique stereochemistry.

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7 questions

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1.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is another name for the enzyme aconitase?

Aconitate hydratase

Citrate synthase

Isocitrate dehydrogenase

Fumarase

2.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the first step in the mechanism of aconitase?

Oxidation of a substrate

Hydration of a double bond

Proton transfer

Formation of an alkene

3.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What type of elimination process is involved in the aconitase mechanism?

E1

SN2

SN1

E2

4.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What is the configuration of the double bond in cis-aconitate?

E

Z

R

S

5.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What happens to histidine in the final steps of the aconitase mechanism?

It is reduced

It is deprotonated

It is oxidized

It is re-protonated

6.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

What type of addition is observed in the formation of isocitrate?

Radical addition

Anti addition

Nucleophilic addition

Syn addition

7.

MULTIPLE CHOICE QUESTION

30 sec • 1 pt

Which molecule is specifically formed as a result of the aconitase reaction?

Citrate

Malate

Isocitrate

Fumarate