TCA Cycle 1

The video explores the TCA cycle, focusing on reactions up to succinyl CoA production. It distinguishes between pathways and cycles, emphasizing the regeneration of citrate. Key reactions include those catalyzed by citrate synthase, aconitase, isocitrate dehydrogenase, and alpha-ketoglutarate dehydrogenase. The video highlights the allosteric regulation of these enzymes and discusses the energy yield and carbon tracking within the cycle.

Explain the difference between a pathway and a cycle in biochemical terms.

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What is the significance of citrate synthase in the TCA cycle?

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What are the three carboxylates present in citrate?

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What role does aconitase play in the TCA cycle?

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Describe the mechanism of isocitrate dehydrogenase and its products.

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How does alpha-ketoglutarate dehydrogenase relate to pyruvate dehydrogenase?

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What is the final product generated by the alpha-ketoglutarate dehydrogenase complex?

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Discuss the allosteric regulation of enzymes in the TCA cycle.

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Explain the energy yield from the TCA cycle up to succinyl CoA.

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What is the significance of NADH production in the TCA cycle?

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