Oxaloacetate Metabolism

The video explores gluconeogenesis, focusing on the transport of oxaloacetate from the mitochondria to the cytosol. It explains the conversion of pyruvate to oxaloacetate, the role of malate as a shuttle, and the formation of phosphoenolpyruvate. Two pathways are discussed: one involving cytosolic PEP carboxykinase and another using mitochondrial PEP carboxykinase. The video concludes with a brief mention of glycolysis and gluconeogenesis regulation by phosphofructokinase 2.

What is the role of pyruvate carboxylase in gluconeogenesis?

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Explain why oxaloacetate cannot exit the mitochondria.

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Describe the process of converting oxaloacetate to malate.

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What is the significance of the malate transporters in the mitochondrial membrane?

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What happens to malate once it exits the mitochondria?

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How does phosphoenolpyruvate (PEP) get generated in gluconeogenesis?

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Discuss the relationship between glycolysis and gluconeogenesis in terms of enzyme usage.

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