Porphobilinogen Synthase: Physiology, Biochemistry, and Organic/Inorganic Mechanism

The video tutorial explores the synthesis of delta aminolevulinic acid in mitochondria and its transport to the cytosol for heme production. It highlights the role of porphobilinogen synthase in converting delta aminolevulinic acid to porphobilinogen, a precursor for heme and other molecules. The enzyme's inhibition by lead and its genetic deficiency, known as aminolevulinic acid dehydratase deficiency or DOS porphyria, are discussed. The video also delves into the enzyme's mechanism, focusing on the role of zinc and lysine residues in the active site.

Explain the process of allosteric regulation in the context of porphobilinogen synthase.

What are the potential symptoms of porphyria related to delta aminolevulinic acid dehydratase deficiency?

Discuss the role of zinc in the active site of porphobilinogen synthase.

What is the final product of the reaction catalyzed by porphobilinogen synthase?