Drugs & Xenobiotics | Mechanisms of Arsenic Poisoning

The video explains arsenic poisoning mechanisms, focusing on arsenate's disruption of glycolysis and arsenite's impact on the TCA cycle. It details how arsenate mimics phosphate, affecting ATP production, and how arsenite inhibits key enzymes, disrupting metabolism. An antidote, 2-3 dimer capto propanol, is discussed for its ability to restore enzyme function. The video concludes with a historical anecdote about President Harding's alleged arsenic poisoning.

How does arsenic poisoning lead to a reduction in ATP generation during glycolysis?

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What is the significance of the antidote 2-3 dimer capto propanol in arsenic poisoning?

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Summarize the story about Warren G. Harding and arsenic poisoning mentioned in the text.

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