Macroautophagy | Transcriptional Regulation: Lesson 1

The video tutorial discusses the regulation of macroautophagy, focusing on transcriptional activators. It covers various transcription factors like TFEB, E2F1, ATF4, FOXO3, NRF2, HIF1, P53, and PPAR Alpha, explaining their roles in regulating macroautophagy through transcriptional regulation. The tutorial also highlights the conditions under which these factors are activated and their specific targets within the macroautophagy pathway.

What transcription factors are involved in the regulation of macroautophagy?

What is the role of TFEB in the regulation of macroautophagy?

How do transcriptional repressors like NF Kappa B affect macroautophagy?

What are the key proteins upregulated by TFEB in the macroautophagy pathway?

How does E2F1 contribute to the macroautophagy pathway?

Explain the impact of hypoxia on ATF4 and its role in macroautophagy.

What are the effects of FOXO3 activation on the macroautophagy pathway?

Discuss the role of HIF1 in macroautophagy under hypoxic conditions.

Describe how P53 influences macroautophagy in response to DNA damage.

What is the relationship between PPAR alpha and macroautophagy during fasting?