RANKL and Osteoclast Signaling

The video tutorial explains the RANKL/RANK/OPG signaling pathway, focusing on its role in bone metabolism. RANKL, expressed by osteoblasts, binds to RANK on osteoclast precursors, promoting their differentiation and activation, leading to bone resorption. OPG, also expressed by osteoblasts, inhibits RANKL, protecting against bone loss. The tutorial also covers intracellular signaling pathways activated by RANK, including TRAF6, which promotes osteoclast survival and differentiation. The video concludes with a summary of the pathway's importance in bone health.

What does RANKL stand for in the context of bone cell signaling?

• Receptor Activator of Nuclear Factor Kappa B Ligand

• Receptor Activator of Neuronal Factor Kappa C Ligand

• Receptor Activator of Neuronal Factor Kappa B Ligand

• Receptor Activator of Nuclear Factor Kappa C Ligand

Which protein inhibits RANKL and helps protect against bone loss?

• RANK

• OPG

• TRAF6

• SRC

What role does OPG play in the RANKL-RANK signaling pathway?

• It degrades RANKL

• It binds to RANK

• It inhibits RANKL

• It activates RANKL

How do estrogens like estradiol affect the release of RANKL?

• They increase the release of RANKL

• They decrease the release of RANKL

• They have no effect on RANKL release

• They convert RANKL to another protein

What happens to osteoclast precursors when RANKL binds to RANK?

• They become inactive

• They die

• They differentiate into mature osteoclasts

• They become osteoblasts

What is the result of osteoclast precursor differentiation?

• Formation of osteoblasts

• Formation of bone marrow

• Formation of multinucleated osteoclasts

• Formation of mononucleated osteoclasts

Which protein is activated by the RANK receptor to promote osteoclast survival and growth?

• RANKL

• TRAF6

• OPG

• SRC

What is the role of the PI3 kinase pathway in osteoclasts?

• It converts osteoclasts to osteoblasts

• It inhibits osteoclast differentiation

• It promotes osteoclast survival and growth

• It deactivates osteoclasts

Which signaling pathway is involved in osteoclast precursor differentiation?

• MAPK signaling

• Notch signaling

• NF kappa-B signaling

• Wnt signaling

What is the ultimate effect of the RANKL-RANK-OPG signaling pathway on bone?

• Bone resorption

• Bone repair

• Bone formation

• Bone mineralization