Glutamate Dehydrogenase Catabolism of Glutamate

The video tutorial explains the mechanism of glutamate dehydrogenase, focusing on oxidative deamination. It describes how glutamate is converted into ammonia and alpha-ketoglutarate, with ammonia entering the urea cycle and alpha-ketoglutarate entering the TCA cycle. The enzyme can use either NAD or NADP, and the process involves Schiff base formation and hydrolysis. The tutorial highlights the enzyme's mitochondrial location and its role in glutamate catabolism.

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