Prions | Mechanisms and Theories of Alzheimers Disease (Amyloid & Tau)

The video explores Alzheimer's disease, focusing on two main hypotheses: the Tau hypothesis and the beta amyloid hypothesis. The Tau hypothesis involves the misfolding of Tau proteins leading to microtubule destabilization and neurofibrillary tangles. The beta amyloid hypothesis involves the formation of amyloid plaques from misfolded beta amyloid proteins, disrupting calcium homeostasis and inducing apoptosis. Both hypotheses contribute to neurodegeneration, with cross-talk between them. Treatments like acetylcholinesterase inhibitors are discussed, though no cure exists.

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