Which of the following anti-clotting substances acts on factors V and VIII

Patients with which of the following diseases may have a normal PTT?

true regarding TTP

A twenty-seven year-old woman complains of heavy menstrual periods, ease of bruising and excessive bleeding following a dental procedure. She has a normal platelet count, normal PT, but slightly prolonged aPTT. Of the following, the test that will most likely make the diagnosis is.

Features of the antiphosopholipid syndrome include all of the following except

The following picture is of an uncommon complication of Coumadin use. It is known as Coumadin skin necrosis, and occurs because

von Willebrand factor adheres platelets to exposed subendothelial collagen via

Platelets aggregate with each other with the help of fibrinogen that binds to

thrombin activates following factors, except

follwoing are content of alpha granule of platelet, except

which is the follwoing is intrinsic 10ase

clot retraction is mediated by

antithrombin inhibits the following except

urokinase activates

circulating plasmin is inhibited by the following except

A 7 year old girl requiring a tonsillectomy and adenoidectomy undergoes pre-operative laboratory testing by her surgeon revealing a prolonged activated partial thromboplastin time (PTT) of 150 seconds (normal range 22-36 seconds). Her prothrombin time (PT) is normal. She had previously had 2 dental extractions that were uneventful. She otherwise has no personal or family history of bleeding. Which of the following is most likely:

You are evaluating a 12 year girl who was admitted to the hospital for anemia (hemoglobin concentration of 85 gm/L) who has had significant vaginal bleeding with the onset of menarche 3 weeks ago. Her family history includes several females who were diagnosed with von Willebrand disease (VWD). Which of the following tests are necessary to detect the presence of type 2A VWD?

A 1 year old male presents to the emergency room with irritability and vomiting, and a CT scan demonstrates a large intracranial parenchymal hemorrhage. The mother reports that his only other bleeding symptom was prolonged bleeding from the umbilical stump. The patient comes from a large pedigree with numerous male and female first and second degree relatives, however there is no history of excessive bleeding in any of them. Which of the laboratory test patterns are most consistent with this history?

You are seeing a 12 year boy old with easy bruising and recurrent epistaxis as a second opinion. He is active in a variety of sports, however his mother feels that his bruising is excessive. His pediatrician sent the following laboratory tests all of which are normal: WBC, Hemoglobin, platelet count, PT, PTT. Another hematologist ordered the following all of which were normal: VWF Ag, ristocetin cofactor activity, factor VIII activity, factor XIII activity, and platelet aggregation studies. Which of the following physical exam findings would be most informative:

A 4 year old male is in the intensive care unit intubated and sedated. You are asked to consult due to the presence of numerous generalized petechiae and some large ecchymosis on the abdomen and trunk. Laboratory evaluation demonstrates a platelet count of 45 x 10⁹/L, a PT 15.4 seconds (normal 9.7-11.2 seconds), a PTT of 48 seconds (normal 22-36 seconds), and a fibrinogen level of 0.87 g/L (normal 2-4 g/L). Which of the following most likely led to these clinical findings:

A 3 day old infant is brought to the ER due to a seizure. A CT scan demonstrates massive intracranial hemorrhage. On your examination, the child has numerous bruises on the abdomen and trunk. Which of the below scenarios is most likely

A 36-year-old woman with a longstanding history of menorrhagia, mucocutaneous bleeding, and easy bruising is referred for further evaluation. Hemoglobin is 9.8 g/dL, mean corpuscular volume (MCV) is 74 fL, platelets are 86,000 x 109/L, and white blood cell (WBC) count is normal. Prothrombin time (PT) and partial thromboplastin time (PTT) are normal. Further workup shows von Willebrand factor (vWF) activity (ristocetin cofactor assay) is 26%, vWF antigen is 58%, factor VIII is 96%. Multimer analysis reveals no high-molecular-weight multimers. Platelet aggregometry shows aggregation with 0.5 mg/mL of ristocetin. Which is the most likely diagnosis?

A 34-year-old man with limited medical history presents with recurrent epistaxis and prolonged bleeding following a dental extraction. He notes a history of easy bruising. His nose bleeds last for up to an hour and he has required medical intervention on several occasions to control the bleeding. A complete blood count (CBC) shows mild thrombocytopenia (134 x 109/L) but is otherwise normal. Prothrombin time (PT) and partial thromboplastin time (PTT) are normal. Review of the peripheral blood smear shows giant platelets. Which of the following is most likely to support the diagnosis?

A 65-year-old female, G2P2, is referred after screening labs performed prior to an elective cholecystectomy revealed a prolonged activated partial thromboplastin time (aPTT) of 67 seconds. The patient denies a history of easy bruising or menorrhagia. She has tolerated numerous operations including a bowel resection and appendectomy without any bleeding complications. She has never required a blood transfusion and denies mucocutaneous bleeding. Review of her medical records reveals her aPTT has been prolonged for many years, even before these operations. Physical exam is unremarkable. Complete blood count (CBC) and prothrombin time (PT) are normal. The aPTT corrects when mixed with an equal volume of normal plasma. Which is the most likely diagnosis?

A 64-year-old male who is currently receiving adjuvant chemotherapy for colon cancer was recently hospitalized for neutropenic fever. In addition to thrombocytopenia, he was found to have an abnormal activated partial thromboplastin time (aPTT) of 52 seconds. Prothrombin time in the hospital was 12 seconds. He is referred for further evaluation. He denies any recent or historic bleeding, but has had a blood transfusion during the course of his colon surgery and chemotherapy. He has no personal or family history of thrombosis. Hemoglobin is 9.6 g/dL, platelets 136 x 109/L, white blood cells (WBCs) 6.4 x 109/L. His exam shows scattered small ecchymoses and no splenomegaly. What is the best next step for his evaluation?

Which of the following facts about von Willebrand factor (vWF) is correct?

A 65-year-old male with a history of obesity, nicotine dependence, obstructive sleep apnea, and coronary artery disease presents with a 3-day history of worsening abdominal pain. A CT abdomen shows an acute, occluding portal vein thrombosis but an otherwise normal-appearing liver. Labs show a hemoglobin of 17.6 g/dL, hematocrit of 50%, white blood cell count of 9.2 x 109/L, and platelets are 395 x 109/L. Renal and liver function tests are normal. Lactate dehydrogenase (LDH), haptoglobin, and a peripheral blood smear are normal. Urine dipstick and microscopy are also normal. Which of the following is the most likely to explain the cause of this patient's thrombosis?

Which factor has shortest half-life?

Joint hematoma (hemarthosis) can be seen in all, except

The chances of the daughter of a severe hemophilia A to be a carrier

are:

Which of the following is not true about stabilization of platelet plug

by fibrin?

A 17 years old girl underwent tonsillectomy at the age of 3 years and had no bleeding. Now she is planned for elective major surgery and during pre-anesthetic workup she was found to be having prolonged APTT with normal PT. There is no family history of any bleeding diathesis. The diagnosis is:

A lady of 36 years age present with prolonged APTT with normal PT and platelet count. There is no history of any bleeding. She had a major surgery done 3 years back without any bleeding complication. What next test should be done in this patient?

Which of the following test may help in differentiating hemophilia A from vWD?

Which of these statements is not true regarding platelets?

In Thrombotic Thrombocytopenic Purpura (TTP) which of the

following is true?

Bernard – Soulier syndrome is characterized by all except:

Which of the following does not inhibit platelet activation?

Macrothrombocytopenia is characteristically seen in all, except:

Which of the following is not true about Wiskott–Aldrich syndrome

Five days after starting warfarin therapy in a patient of atrial fibrillation the 60 year old man returns to his physician complaining of large patches of discolored stain over his gluteal region and legs. This complication is most likely the result of:

LMWH inhibits the following, except