NEW
Font size
WorksheetsBiochem 3
Total questions: 68
Worksheet time: 2hrs 16mins
Wet beriberi is a deficiency of what vitamin?
B1
B2
Niacin
B5
The coenzyme FADH2 is used in electron transfer reactions. What vitamin makes it?
Riboflavin
B5
B1
Pyridoxal
NADPH and NADH are coenzymes made from which vitamin?
B2
K
B3
C
What vitamin is required for the synthesis of CoA?
B1
Riboflavin
B6
B5
Vitamin B6 is required to make catecholamine NTs and for trans animation reactions. It is also important for Na/K balance and the production of ___________.
WBCs
RBCs
Bones
Urine
B7(Biotin) is required as a coenzyme for enzymes that add what type of group?
phosphorylation
Carboxyl
Hydroxyl
NADPH
Folic acid(B9) deficiency can cause fetal birth defects. It is used in what type of synthesis?
Glucogen
Nucleotide
ATP
NADH
Cyanocobalamin(B12) deficiency can cause pernicious anemia. What absorbs B12?
Extrinsic factor
Intrinsic factor
Cholesterol
Calcitonin
Vitamin C causes Scurvy due to the fact that Vitamin C is important in the synthesis of what?
NADH
Collagen
FADH2
Nucleotides
Hyperkalemia can lead to what issue?
Vomiting
Arrhythmia
Kidney Stones
Anemia
Magnesium(Mg2+) helps stabilize what molecule?
H2O
ATP
Calcitrol
CO2
In the mouth the demineralization process starts when pyruvate converts to what?
A-amylase
Lingual lipase
Lactic acid
Glucose
Taste bud formation is started by what saliva-produced hormone?
Lingual lipase
A-amylase
Gustin
Mucus
Some sulfur-containing molecules are detoxified by what saliva enzyme?
Superoxide dismutase
Glutathione transferase
Mucus
A-amylase
Methamphetamines can cause the overstimulation of the sympathetic and increase the demand for ATP. It also restricts saliva flow causing meth mouth via acting on which receptor type?
B-adrenergic receptors
A-adrenergic receptors
Histamine receptors
Gastrin receptors
The stimulation of C kinase produces protective enzymes and mucin from which cell type?
Foveolar cells
Oxyntic cells
Chief cells
ELCs
Parietal cells are stimulated by Gastrin to secrete what into the stomach?
Histamine
Gastric acid
Bicarbonate
Pepsinogen
Most antihistamine blockers are H1 receptors. H1 receptors activate which G protein to cause flushing of the blood vessels?
Gs protein
Gi protein
G1 protein
Gq protein
A-amylase is secreted from which digestive organ?
Stomach
Mouth
Ileum
Duodenum
H3 receptors use Gi proteins to inhibit the release of NTs, such as GABA, by inhibiting which enzyme?
Hexokinase
Adenylyl cyclase
lipase
Amylase
Chief cells produce pepsinogen. They also produce what enzyme to help infants absorb milk?
Gastrin
Secretin
Rennin
Pepsin
ELCs histamine secretion is inhibited by what?
Gastrin
Gastric acid
Somatostatin
Vagus nerve
G cells secretion of gastrin can be increased by what structure, causing the release of gastrin-releasing peptide?
Vagus nerve
Prostaglandins
Smooth Muscle
Phrenic nerve
Which hormone produced in the duodenum causes the gall bladder to contract and pancreatic digestive enzymes to be secreted?
Gastrin
Secretin
Somatostatin
CCK
If you had undigested proteins in the stomach what molecule would stimulate the secretion of pepsinogen by the Chief cells?
CCK
Rennin
GIP
Gastrin
What molecule reduces the acidity of digestive food entering the duodenum?
VIP
Motilin
GIP
Secretin
Before H2 blockers, doctors would do a vagotomy in order to treat what disease before it progressed to a potentially fatal adenocarcinoma?
GERD
Alcohol detoxification
Achlorhydria
Scurvy
In order to detoxify toxins in the liver increases the polar nature of the toxin by using what?
Cytochrome p450 system
RAS system
Kinase
CoA dehydrogenase
Brunner’s gland of the duodenum releases mucus and what else?
Gastric acid
Alkaline solution
Pepsin
CCK
B12 is absorbed by an intrinsic factor in which organ of the digestive tract?
Jejunum
Duodenum
Ileum
Stomach
The cytoskeleton of a cell is made of what filament type?
G-actin
F-actin
Myosin
Tropomyosin
When Ca is released from the SR, which molecule creates a conformational change to expose the actin binding sites?
Tropomyosin
Troponin C
Troponin T
Troponin I
Movement of vesicles down the F-actin is most likely preformed by which molecule?
Myosin II
Myosin I
Troponin T
Troponin C
In smooth muscles CICR, increased Ca causes Rho kinase to inhibit MLCP. The binding of Ca to what molecule causes MLCK to activate myosin?
Calcitonin
Calcitrol
Calmodulin
Troponin C
Chemical warfare nerve agents cause continuous depolarization at the NMJ by binding to what molecule?
NE
ACh
Acetylcholinesterase
Adrenergicase
Running a marathon allows your muscles to use O2 to produce energy from FAs. What allows this muscle type to store O2?
Myoglobin
Creatine phosphate
Glycogen
WBC
In cardiac and smooth muscle CICR, L-type Ca channels/dihydropyridine receptors induces Ca to flow into the sarcoplasm. This Ca will release more Ca from the SR by binding to what receptor?
A-adrenergic receptor
B-adrenergic receptor
Ryanodine receptor
Gq protein
Creatine phosphate, a quick way for the muscle to make ATP, is created by using what enzyme?
Creatine kinase
Creatine phosphatase
Creatinase
Creatine decarboxylase
What molecule can walk along the microtubule network to move chromosomes during mitosis?
Axonemal dyein
Cytoplasmic dyein
Myosin I
Myosin II
What intermediate filament protein links together the 9 microtubule doublets of the cilia or flagella?
Nexin
Radial spokes
F-actin
Myosin
The amount of Heme in the mitochondria regulates the rate limiting step of Heme synthesis. What enzyme is being regulated?
ALA synthase
Ferrochelatase
PLP
Kinase
Carbon monoxide causes issues due the fact it has a higher affinity for what molecule than O2?
Hemoglobin
Myosin
Actin
Thrombin
A genetic disease that decreases the activity of an enzyme for HEME synthesis is known as ______.
Porphyria
Thalassemias
Sickle cell anemia
Iron deficiency anemia
Increased temperature causes T state, a shifts of the O2 curve to the right. This shift causes O2 to do what?
Bind to Hgb in the lungs
Transfer to tissues
O2 released to the tissues is caused by a negative allosteric regulation of Hgb. What molecule can cause this release by stabilizing the T state through a series of ionic interactions?
2,3-BPG
Protoprophyrin
NADPH
Thalassemia
The decrease in the oxygen affinity of a respiratory pigment, such as Hgb, in response to a decreased blood pH resulting from increased CO2 concentration in the blood is known as the _____________.
O2 dissociation curve
Sigmoidal curve
Bohr effect
Neagative allosteric effector
Lower pO2 resulting in the reduction of O2 saturation is known as __________.
Iron deficiency anemia
Sickle cell anemia
Altitude sickness
Porphyria
Hydroxyurea can replace B-globin with y-globin in the Hgb molecule. This treatment can help someone who has what disease?
Sickle cell disease
Iron deficiency anemia
Altitude sickness
Carbon monoxide poisoning
vWF deficiency decreases rather survival of factor VIII. vWF is important because it enhances what step of platelet plug formation?
Adhesion
Aggregation
Activation
Decomposition
Platelet plug formation can be limited by giving NSAIDs. Which NSAID blocks Thromboxane A2?
Indomethacin
Ibuprofen
Aspirin
The intrinsic pathway and the extrinsic pathway both get cleaved into Factor VIIa, which both end up activating what factor?
II
XII
X
IX
What is the committing step in clot formation?
Factor III
Factor X
Thrombin
Fibrin
Clot formation regulation is done by 3 major regulators. Anti-Thrombin III is one of them and can be enhanced by what molecule?
Hgb
Heparin
Protein C
Protein S
Preprocollagen has it's signal peptides removed to form Procollagen. This part of collagen synthesis takes place in the lumen of what organelle?
RER
SER
Golgi apparatus
Cytoplasm
Type I collagen can have a point mutation that destabilizes collagen’s triple helix structure causing which disease?
Osteoporosis
Osteogenesis Imperfecta
Scurvy
HANAC
Which bone matrix type is made of calcium hydroxyapatite?
Organic
Inorganic
A TGF-B dimer attaches to cell membrane receptors which cause a chain reaction creating SMAD4/RSMAD. This molecule then enter the nucleus and activates genes. TGF-B affects the growth of which cell type?
Osteoclasts
Osteocytes
Osteoblasts
New osteoblasts help promote the growth of osteoclasts by secreting what cytokine?
Osteocalcin
Osteonectin
M-CSF
RANK-L
In the womb, if the BMPI gene is not deactivated it can cause kids to have deformed big toes, leading you to think the kid has what disease?
FOP
Osteogenesis
Osteoarthritis
Rickets
OPG is used to inhibit RANK, this blocks the development of what cell type?
Osteoblasts
Osteoclasts
Osteocytes
NaF, strontium, and OPG analogues are treatments for what disorder?
Osteoporosis
Rickets
Osteoarthritis
FOP
PTH increases calcitriol in the small intestines which in turn increases what Ca binding protein?
Calbindin
Calcitonin
M-CSF
OPG
A deficiency in which vitamin can cause lead to an increase in PTH to compensate? This deficiency can cause rickets and osteomalacia.
D
K
C
B12
Parafollicular cells produce what molecule to reduce blood Ca?
Calcitriol
Calbindin
Calcitonin
Calbulumin
Which vitamins are fat soluble?
A, D, E, K
B, C
Hypoxia afters a few days wants the body to create more RBCs. They body does this by secreting Epo to activate which signaling cascade?
CICR
JAK-STAT
CN V
Transferrin
Protein C and S work together to inactivate which clotting factors?
Thrombin, IXa, Xa, XIa
Va, VIIIa
Va
Xa, VIIa
If Factor XII was to encounter exposed collagen it would set off what clotting cascade pathway?
Extrinsic
Intrinsic
