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WorksheetsGI Midterm
Total questions: 48
Worksheet time: 48mins
A 62yo male with a history of alcohol abuse presents with bright red blood in his vomit. On physical examination, you note abdominal swelling and erythema on both palms. He is notably tachycardic. The anastomoses of which of the following has contributed to his condition?
R. gastric v. and azygous v.
L. gastric v. and azygous v.
L. gastric v. and superficial epigastric v.
Paraumbilical v. and superficial epigastric v.
Paraumbilical v and azygous v.
The structure indicated by the circle most likely (select all that apply):
Reabsorbs Na+, releases K+ and HCO3-
Reabsorbs Cl-, releases HCO3-
Reabsorbs Na+, releases K+
Reabsorbs K+, releases K+
Reabsorbs HCO3-, releases Cl-
The peak of this smooth muscle action potential is most likely due to:
Na+ influx
Ca2+ influx
K+ influx
Cl- efflux
H+ influx
Which of the following changes will most likely inhibit smooth muscle relaxation?
Decreased MLCK
Decreased L-arginine
Increased cGMP
Increased MLCP
Increased proportion of myosin-P + actin
A young female presents with significant bone loss around her teeth, but you note a lack of inflammation. The pictured culture is grown. What is the most likely pathogen associated with her presentation?
Fusobacterium nucleatum
Treponema spp.
Veillonella spp.
Actinomyces israelii
Aggregatibacter actinomycetemcomitans
Which of the following is generally incompatible with life?
Esophageal stenosis
Esophageal atresia
Pyloric stenosis
Gastroschysis
Diaphragmatic hernia
Absence of which of the following would most impair the digestion of alpha1,6 bonds?
Glucoamylase
Lactase
Isomaltase
Sucrase
Maltase
Within the first 48 hours of starvation, which of the following serves as the main fuel source?
Glucose
Fatty acids
Amino acids
Ketones
Which of the following does not reflect the MAIN functions of TLR signaling in the GI tract?
Produce factors promoting motility and repair
Promote B cell production of sIgA
Maintenance of tight junctions
Expression of AMPs
Promote inflammatory response
Which of the following is the most abundant source of dietary fat?
Phospholipids
Triacylglycerols
Free cholesterol
Cholesterol esters
Phosphoglycerides
Patient presents with painless, mobile mass on their parotid gland. You slice it open and observe the pictured finding. What is most likely concerning this mass?
Associated with elevated risk of sterility
Associated with autoimmune diseases
Composed of squamous and mucus secreting cells
Malignant
Can result in malignant transformation
In protein digestion, which of the following is active first?
Trypsin
Pepsin
Enteropeptidase
Chymotrypsin
Carboxypeptidase A
Elderly patient with recent history of pneumonia presents with punched out ulcerations in the esophagus and the pictured findings. You would most expect:
Cytoplasmic inclusions
Nuclear and cytoplasmic inclusions
Presence of HPV
Presence of HSV
Presence of EBV
Deficiency of which of the following would most likely impair the activity of glutathione peroxidase?
Vitamin B9
Vitamin B12
Selenium
Zinc
Iron
Which of the following cells is most responsible for stimulating secretion of pancreatic enzymes?
G
I
S
K
Gr
Which of the following is not a typical level of narrowing associated with foreign body obstruction?T
C6
C8
T4
T6
T11
Male pt presents with the complain of severe chest pain. On auscultation, you note a rasping sound synchronous with his heart beat over the precordium. The pt's condition is most likely associated with:
Superficial tear in the mucous membrane of esophagus
Self-resolution in 7-10 days
Pyopneumothorax
Hiatal hernia
Caused by sudden decrease in intraesophageal pressure
An elderly male patient is complaining of persistent cough, keeps regurgitating his meds, and has a feeling "like a lump in his throat." You note that his voice is hoarse and his breath is awful. What is most likely?
Esophageal stricture
Cafe coronary
Steakhouse syndrome
Esophageal web
Zenker's diverticulum
While traveling the Oregon Trail, Terry experiences fever, cramps, and tenesmus. He violently covers the entire wagon in bloody stool, teeming with PMNs. If you had modern tools, what would you discover?
A toxin that inactivates the 60s ribosomal subunit
Pink colonies on MacConkey agar
Motile, spore forming bacteria
Facultative intracellular aerobe
Yellow colonies on TCBS agar
You obtain the pictured findings from a pt complaining of watery diarrhea. The patient notes that he was recently treated for a UTI. What is true regarding the likely pathogen?
Catalase +
Oxidase +
Gram positive bacilli
Immotile
Produces alpha toxin
You cultured a pathogen on MacConkey agar and found pink colonies. The picture results also occurred on SS agar. What is true regarding the likely pathogen?
Possesses H antigen
Often vancomycin resistant
Symptoms mimic appendicitis
Has LPS associated with autoimmune nerve damage
Distinct gull-wing shape
18mo old presents w/ vomiting, fever, diarrhea, and shows signs of severe dehydration. What else is true regarding this strain of E. coli?
Zoonotic
Primarily intracellular
Expresses EAF
Associated w/ HUS
Emerging cause of traveler's diarrhea
The pictured finding (pt sample on the right) came from a patient with diarrhea after eating a large amount of chicken. What is true regarding the causative agent?
Grows on TCBS agar
Cannot be transmitted zoonoticatlly
No growth on MacConkey agar
Growth on Skirrow agar
Culture requires cold enrichment
Which of the following endotoxins does not produce diarrhea on its own?
LT1
LT2
STa
STb
EAST1
Which of the following is associated with severe burns?
Stress ulcer
Curling ulcer
Cushing ulcer
Perforation ulcer
Shock ulcer
Pt presents with nausea and upper abdominal discomfort. You perform a urea breath test and it is positive. Where did this biopsy most likely come from?
Fundus of stomach
Body of stomach
Cardia of stomach
Antrum of stomach
Proximal duodenum
Middle aged male pt presents with complaints of epigastric burning sensation. He has a history of renal disease and mentions that he has gained 5lbs this month because eating seems to help his pain. What is most likely?
Gastric peptic ulcer
Duodenal peptic ulcer
Acute gastritis
Chronic gastritis
Zollinger-Ellison syndrome
You are treating a pt with a history of heart disease for peptic ulcer disease and he begins complaining of nausea, vomiting, abdominal pain, diarrhea, and yellowed vision. What side effects are associated with the drug you gave him for PUD?
Inhibition of 5 alpha reductase
Inhibition of multiple CYP P450 isoforms
Vitamin B12 deficiency
Short duration
Teratogenic
Pt has begun a new drug regimen and calls you complaining about dizziness and headache. She seems very confused and keeps yelling about the milk. THE MILK! What did you give this patient?
Colloidal bismuth
Cimetidine
Magnesium hydroxide
Aluminum hydroxide
Sodium bicarbonate
You are treating a pt with an H. pylori infection that was unresponsive to the first line therapy. What do now?
Omeprazole QD, Clarithromycin BID, Amoxicillin BID
Omeprazole QD, Clarithromycin BID, Metronidazole BID
Omeprazole QD, Bismuth subsalicylate QID, Metronidazole QID, Tetracycline QID
Famotidine BID, Bismuth subsalicylate QID, Metronidazole QID
Omeprazole QD, Bismuth subsalicylate QID
Pt with type A blood that has a steady diet of smoked foods comes in for a gastric biopsy. Based on the pictured finding, what do you think?
Diffuse gastric adenocarcinoma
Intestinal gastric adenocarcinoma
Carcinoid tumor
Gastrointestinal stromal cell tumor
The pictured neoplasm is most likely associated with:
Elevated 5H1AA in urine
Increased production of IL-1Beta
Germ line mutation of CDH1
KIT gain of function mutation
PDGFRA loss of function mutation
This biopsy was taken from a mass found in the proximal duodenum of a patient with symptoms similar to peptic ulcer disease, biliary obstruction, and abdominal pain. The tumor most likely secretes:
Histamine
Serotonin
Gastrin
Substance P
Polypeptide YY
You are treating a pt on chemotherapy for N/V with dolasetron. What drug could you add to this to enhance is efficacy?
Diphenhydramine
Dimenhydrinate
Dexamethasone
Droperidol
Dronabinol
Pregnant pt w/ N/V in the 1st trimester. Blood work is negative for ketosis and she reports no significant weight changes. Which treatment would present the greatest risk?
Promethazine
Odansetron
Metoclopramide
Diphenhydramine
Doxylamine/pyridoxine
You are treating a pt with diarrhea using ciprofloxacin. They complain of recent nausea, so why not toss a few more drugs at them? You include odansetron and dexamethasone. What DDI is most concerning?
CYP3A4 inhibtion
CYP3A4 induction
Prolonged QT interval
Increased risk of tendon rupture
Respiratory depression
Which of the following is the GOLD standard for assessing body fat and lean body mass?
BIA
DEXA
MRI
Bod Pod
CT Scan
Which of the following is true regarding Kwashiokor vs Marasmus?
Elevated protein intake
Lower mortality
Mildly catabolic
Takes months to develop
Well-nourished appearance
What is the minimum daily protein intake?
0.4 g/kg body wt
0.5 g/kg body wt
0.65 g/kg body wt
0.8 g/kg body wt
1.5 g/kg body wt
Pt w/ N/V and diarrhea. He said that he's been eating lots of salad to lose weight lately. The cultures show off-white colonies on MacConkey agar and black colonies on SS agar. What else is true about this pathogen?
Immotile
Gram + rod
Aerobic
Associated w/ pseudomembrane formation
Enters only M cells
Pt w/ blurred vision and droopy eyelids. You have the pictured findings. What is true about this organism?
No association w/ food intoxication
Toxin cannot cross BBB
Promotes release of ACh
Does not form spores
Grows on MacConkey agar
Pt w/ watery diarrhea and abdominal pain. She mentions having leftover fried rice for breakfast. How does the enterotoxin from the most likely pathogen function?
Stimulation of vagus n.
Upregulation of cAMP
Cleavage of SNARE proteins
Inhibition of gastric acid secretion
Forms pores in phagolysosomal membrane
You work in a geriatric ward and a patient has recently developed diarrhea, vomiting, and a mild fever. You determine that the infectious agent has 11 segments (don't ask me why you did that first) and diagnosed the pt using electron microscopy. What segment of this pathogen's genome stimulates a change in intracellular Ca2+ concentration?
VP3
NSP1
NSP2
NSP3
NSP4
A pt has awful gastroenteritis after eating at a cruise ship buffet in December on a Wednesday and 5:39 PM. What is true regarding the immune response to this pathogen?
Immunity conferred via live oral attenuated vaccine
Immunity conferred via killed injectable vaccine
Exposure elicits short term immunity
Exposure elicits long term immunity
It completely evades the immune response
A patient returns from a lovely vacation in the tropics with some uninvited guests. She has loose, bloody stools, stomach pain, and cramps. You note the presence of cysts and trophozoites in her stool. The best option for treatment would be:
Rehydration and bed rest
Metronidazole
Metronidazole and paromycin
Nitazoxanide
Iodoquinol
An obese, 55yo pt with a history of SVT complains of heartburn, difficulty swallowing, and drooling. Barium swallow indicates an incompetent LES. Which of the following would be the gold standard surgical treatment for this condition?
Transoral incisionless fundoplication
Titanium esophageal ring
Bariatric surgery
Laproscopic Nissen fundoplication
Gastric bypass
Pt (BMI 23) with history of asthma has complaints of chronic hoarseness, non-productive cough, difficultly swallowing, and a feeling like a lump in their throat. What is true regarding the suspected condition?
Heartburn is a defining characteristic
HCl plays the most important role in pathogenesis
Damage to larynx/oropharynx occurs after only 3 episodes/day
Reflux is nocturnal or in supine position
Dysfunction of the LES
The majority of patients with GERD symptoms are found to have _______ upon EGD.
Erosive esophaitis
Non-erosive reflux disease
Barrett's Esophagus
Laryngopharyngeal reflux
Esophageal webs
