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Drugs acting on CNS - 1

Total questions: 50

Worksheet time: 25mins

Name
Class
Date
1.

Choose the correct mechanism of action:

a)

BZD - increase duration of opening of chloride channels

b)

Barbiturates - increase frequency of opening of chloride channels

c)

Suvorexant - orexin receptor agonist

d)

Calcium leucovorin - enhance formate metabolism

2.

Disulfiram inhibits alcohol dehyrogenase and helps to treat chronic alcoholism

a)

True

b)

False

3.

Drug having muscle relaxant property

a)

Zopiclone

b)

Diazepam

c)

Dapoxetine

d)

Doxapram

4.

Neuroprotective drug is:

a)

Paroxetine

b)

Piribedil

c)

Promethazine

d)

Piracetam

5.

Gynecomastia is seen with:

a)

Chlorpromazine

b)

Amitryptyline

c)

Selegiline

d)

Sodium valproate

6.

Neiral tube defects are commonly seen with:

a)

Phenytoin

b)

Carbamazepine

c)

Valproate

d)

Lamotrigine

7.

Drug inhibiting GABA metabolism

a)

Pregabalin

b)

Vigabatrin

c)

Tiagabin

d)

Gabapentin

8.

True statement about levodopa is:

a)

It can be used in combination with drugs like clorgyline

b)

Use of carbidopa prevents side effects like dyskinesias

c)

It requires vitamin B6 for its peripheral conversion

d)

It is given half an hour after a meal

9.

Drugs blocking alpha receptors are all except:

a)

Desipramine

b)

Thioridazine

c)

Trazodone

d)

Moclobemide

10.

Anxiolytic drugs

a)

Oxazepam

b)

Propranolol

c)

Temazepam

d)

Sertraline

11.

Enzyme inhibitors are all except

a)

Dapoxetine

b)

Phenobarbitone

c)

Carbidopa

d)

Sodium valproate

12.

Antiepiletic used for treatment of alcoholism

a)

Lamotrigine

b)

Topiramate

c)

Gabapentin

d)

Valproate

13.

Hepatitis is seen with all except:

a)

Valproate

b)

Tolcapone

c)

Carbamazepine

d)

Zonisamide

14.

Acamprosate is a GABA-A activator used in

a)

Chronic alcoholism

b)

Epilepsy

c)

ADHD

d)

Narcolepsy

15.

BZD not given as an oral preparation is:

a)

Midazolam

b)

Alprazolam

c)

Triazolam

d)

Temazepam

16.

A baby was born and its examination revealed a yellow sclera with skin discoloration. No hemolysis was revealed in the blood. The drug that could be administered is:

a)

Diazepam

b)

Phenobarbitone

c)

Lamotrigine

d)

Donepezil

17.

All are used in petit mal epilepsy except:

a)

Clonazepam

b)

Ethosuximide

c)

Valproate

d)

Gabapentin

18.

Drug not affecting sodium transport:

a)

Fosphenytoin

b)

Topiramate

c)

Oxcarbazepine

d)

Ethosuximide

19.

The drug that inhibits catbamazepine metabolism is:

a)

Phenobarbitone

b)

Valproate

c)

Erythromycin

d)

Estrogens

20.

When TCAs are administered with a CNS depressant drug :

a)

Their actions nullify each other

b)

Depression is potentiated

c)

Antidepressive action is potentiated

d)

Causes epilepsy

21.

ADH inhibition is seen with:

a)

Lithium

b)

Carbamazepine

c)

Memantine

d)

Clozapine

22.

Digital vasospasm is specifically seen with:

a)

Bromocriptine

b)

Chlorpromazine

c)

Venlafaxine

d)

Chlordiazepoxide

23.

Livedo reticularis is seen with:

a)

Amantadine

b)

Atomoxetine

c)

Amoxepine

d)

Amphetamine

24.

Agranulocytosis is an important ADR of:

a)

Drug used for bipolar disorder

b)

Antiparkinsonian drug

c)

Antipsychotic reserve drug

d)

Antidepressant drug

25.

Goitre can be caused by:

a)

Carbamazepine

b)

Lithium carbonate

c)

Chlorpromazine

d)

Buspirone

26.

Action of buspirone:

a)

Partial agonist of 5HT-1A receptor

b)

Antagonist of 5HT-1A receptor

c)

Partial agonist of 5-HT2 receptor

d)

Antagonist of 5-HT2 receptor

27.

Drug used in atopic dermatitis:

a)

Donepezil

b)

Doxepin

c)

Imipramine

d)

Mirtazapine

28.

Drug used as psychostimulant:

a)

Doxapram

b)

Modafinil

c)

Citicoline

d)

Piracetam

29.

Status epilepticus is a single episode of epilepsy lasting at least

a)

20 mts

b)

1 hr

c)

30 mts

d)

10 mts

30.

Postherpetic neuralgias can be treated with:

a)

Gabapentin

b)

Amitryptiline

c)

Ziprasidone

d)

Fluphenazine

31.

Central anticholinesterases are used in:

a)

Parkinsonism

b)

Alzheimer's disease

c)

Narcolepsy

d)

ADHD

32.

SSRI that requires administration only once in 3 days

a)

Fluoxetine

b)

Fuloxamine

c)

Dapoxetine

d)

Sertraline

33.

Fluoxetine can cause chlorpromazine toxicity

a)

True

b)

False

34.

Which of the following is a dopamine agonist?

a)

Entacapone

b)

Selegiline

c)

Piribedil

d)

Olanzapine

35.

Which of the following does not precipitate convulsions?

a)

Diazepam

b)

Olanzapine

c)

Nortriptyline

d)

Ropinirole

36.

Floppy baby syndrome is seen with

a)

Phenytoin

b)

Diazepam

c)

Phenobarbitone

d)

Valproate

37.

Which of the following has anriemetic action?

a)

Thioridazine

b)

Amitryptiline

c)

Lamotrigine

d)

Ethosuximide

38.

Thiamine is used in:

a)

Methanol poisoning

b)

Ethanol intoxication

c)

Chronic alcoholism

d)

Alcohol withdrawal

39.

Barbiturate used in general anesthesia

a)

Methohexitone

b)

Pentobarbitone

c)

Phenobarbitone

d)

None of these

40.

Which of the following is not caused by chlorpromazine?

a)

Acute dystonias

b)

Neurolept malignant syndrome

c)

Nausea, vomiting

d)

Tachycardia, palpitations

41.

Choose the correct match/matches.

a)

Mianserin - NA release

b)

Nortryptiline - ADHD

c)

Risperidone - acute mania

d)

Lorazepam - petit mal seizures

42.

Amphetamine & metamphetamine are metabolites of:

a)

MAO-B inhibitors

b)

COMT inhibitors

c)

Dopamine agonists

d)

NMDA receptor antagonists

43.

Which of these drugs are used in Narcolepsy?

a)

Modafinil

b)

Piracetam

c)

Methylphenidate

d)

Atomoxetine

44.

Oxazepam is ideal for liver patients because it is excreted directly without metabolism

a)

True

b)

False

45.

Etizolam has anticonvulsant property unlike zolpidem

a)

True

b)

False

46.

Drug of choice in levodopa induced vomiting

a)

Ondansetron

b)

Metoclopramide

c)

Domperidone

d)

Selegiline

47.

Neuromuscular blockers are inhibited by lithium

a)

True

b)

False

48.

Which of the following does not contribute to depression?

a)

Abnormal HPA axis

b)

BDNF decrease

c)

Thyroid levels

d)

Melatonin levels

49.

Bromocriptine

a)

Strong D1 and D2 agonist

b)

Strong D1 and partial D2 agonist

c)

Strong D2 and partial D1 agonist

d)

Partial agonist at D1 and D2

50.

Uses of Citicoline are:

a)

Vascular dementia

b)

Parkinsonism

c)

Migraine

d)

Stroke

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