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WorksheetsTherapeutic Drug Monitoring
Total questions: 20
Worksheet time: 10mins
Phenytoin gives toxic symptoms when the plasma conc. is greater than
10 µg/mL.
20 µg/mL
30 µg/mL
10 ng/mL
The toxic range of digoxin is greater than
2.5 ng/mL
15.5 ng/mL
25.5 ng/mL
50 ng.mL
Therapeutic range of digoxin is
9.8-12.6ng/mL
3.5-4.0 ng/mL
0.8-2.0 ng/mL
6.6-8.00 ng.mL
Which is the ADR of Phenytoin?
GI bleeding
Red man syndrome
Migraine
Gingival hyperplasia
Therapeutic range of cyclosporine?
500 to 800 ng/mL
100 to 400 ng/mL
200 to 700 ng/mL
500-1000 mcg/mL
The sample collected prior to the administration of next dose is known as
Peak sampling
Trough sampling
infinite conc. sampling
None of the above
To calculate Loading Dose, the parameter required is
Ka
Ke
AUC
Vd
In TDM of cyclosporine, which biological matrix is used?
Plasma
Serum
Saliva
Whole blood
1) TDM is a tool to individualize dosage regimen by maintaining plasma concentration within _______
Dosing interval
Minimum effective concentration
Therapeutic range
Ratio between MEC and MTC as 1:2
In trough sampling, which is considered as good sampling time?
Post dose sampling
Pre dose sampling
Both a & b
None of the above
Drug toxicity studies need
Trough sample
Peak sample
Post dose trough sample
Steady state plasma conc
Therapeutic range of quinidine is
3-8 mcg/mL
4-6 mcg/mL
5-15 mcg/mL
10-15 mcg/mL
The drug that follow non-linear pharmacokinetics is
Theophylline
Amiodarone
Propranolol
Phenytoin
Choose the drug with shortest half-life
Phenobarbital
Phenytoin
Amikacin
Theophyllin
In TDM of digoxin, sample may be collected ------hrs after drug administration
0.5 hrs
1 hr
6 hrs
24 hrs
The action potential prolonging effect of quinidine is observed in the
lower end of therapeutic range
upper end of therapeutic range
end of 4-5 biological half-life
toxic range
What is FPIA
Fluorescence Phosphorescence ImmunogenicAgent
Fluorescence Polarization Immuno Assay
Fluorescence Phosphorescence Immuno Assay
Fluorophore Polarization Immuno Assay
TDM is important for quinidine due to the following reason
The action potential prolonging effect
Potential to cause arrhythmia of Torsade de pointes
Significant inter patient variability in bioavailability
All the above
Hepatic metabolism of quinidine is induced by
Phenytoin
Ketoconazole
Rifampicin
Both a & c
When quinidine is administered with the following drug, there is additive potassium channel blockade
Phenytoin
Rifampicin
both a & b
Erythromycin
